Department of Pediatrics, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
Department of Pediatrics, College of Medicine, Kyung Hee University Medical Center, Kyung Hee University, Seoul, Korea.
J Infect Dis. 2024 Nov 15;230(5):1167-1176. doi: 10.1093/infdis/jiae218.
Rotavirus is linked to severe childhood gastroenteritis and neurological complications, but its impact on neurodevelopment remains uncertain. We examined data from 1 420 941 Korean children born between 2009 and 2011, using the Korean National Health Insurance System. We assessed neurodevelopmental outcomes at age 6 years using the validated Korean Developmental Test, covering 6 major domains, with propensity score-based inverse probability weighting including consideration of covariates sex, birth weight, changes in body weight from birth to 4-6 months of age, head circumference at 4-6 months of age, residence at birth, economic status, infant feeding types, and birth year. The main analysis that encompassed 5451 children with rotavirus hospitalization and 310 874 unexposed individuals revealed heightened odds of suspected delays in fine motor skills and cognition among exposed children. Our results suggest an association between rotavirus-related hospitalization in infancy and suspected delays in fine motor function and cognition in 6 year olds.
轮状病毒与严重的儿童肠胃炎和神经系统并发症有关，但它对神经发育的影响仍不确定。我们使用韩国国家健康保险系统，对 2009 年至 2011 年间出生的 1420941 名韩国儿童的数据进行了研究。我们使用经过验证的韩国发育测试来评估 6 岁时的神经发育结果，该测试涵盖了 6 个主要领域，采用倾向评分逆概率加权法，包括考虑了性别、出生体重、出生至 4-6 个月体重变化、4-6 个月头围、出生时居住地、经济状况、婴儿喂养类型和出生年份等协变量。主要分析纳入了 5451 名轮状病毒住院患儿和 310874 名未暴露个体，结果显示暴露组儿童精细运动技能和认知发育迟缓的可能性更高。我们的研究结果表明，婴儿期轮状病毒相关住院与 6 岁时精细运动功能和认知发育迟缓之间存在关联。
