Sheehan K L, Casper R F, Yen S S
Am J Obstet Gynecol. 1979 Nov 15;135(6):759-63. doi: 10.1016/0002-9378(79)90388-0.
The effect of a potent luteinizing hormone-releasing factor (LRF) agonist (D-Trp6, Pro9 NEt)-LRF on pituitary gonadotropin release and its concomitant ovarian response was examined in normal women during the early follicular (EFP), late follicular (LFP), and midluteal (MLP) phases. A single subcutaneous injection of 50 micrograms of LRF agonist in subjects during the EFP caused prompt release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) to levels comparable to those found during spontaneous midcycle gonadotropin surges, while in LFP subjects gonadotropin levels rose 1 1/2 to 2 times above the levels of midcycle surges. The LH/FSH release in the MLP was almost identical to that found in the EFP. The ovarian response as measured by increasing estradiol levels followed a similar pattern during the 48 hours after injection in all three phases of the cycle. The inappropriate gonadotropin surge induced by LRF agonist in EFP subjects resulted in prolonged follicular phases and anovulation. Three of four subjects in the LFP showed evidence of ovulation in response to the same dose of LRF agonist. The pharmacodynamics of gonadotropin-ovarian responses to this potent LRF agonist reported here should provide an important reference for systemic investigation and rational clinical application.
在正常女性的卵泡早期（EFP）、卵泡晚期（LFP）和黄体中期（MLP），研究了一种强效促黄体生成激素释放因子（LRF）激动剂（D-色氨酸6，脯氨酸9-NEt）-LRF对垂体促性腺激素释放及其伴随的卵巢反应的影响。在EFP阶段，给受试者单次皮下注射50微克LRF激动剂，导致促黄体生成素（LH）和促卵泡生成素（FSH）迅速释放至与自发月经周期中期促性腺激素高峰时相当的水平，而在LFP阶段的受试者中，促性腺激素水平比月经周期中期高峰时的水平高出1.5至2倍。MLP阶段的LH/FSH释放与EFP阶段几乎相同。在注射后的48小时内，通过测量雌二醇水平来衡量的卵巢反应在月经周期的所有三个阶段都遵循类似的模式。LRF激动剂在EFP受试者中诱导的不适当促性腺激素高峰导致卵泡期延长和无排卵。LFP阶段的四名受试者中有三名在接受相同剂量的LRF激动剂后出现排卵迹象。本文报道的这种强效LRF激动剂对促性腺激素-卵巢反应的药效学应为系统研究和合理临床应用提供重要参考。
