Faure N, Olivier G C
Horm Res. 1978;9(1):12-21. doi: 10.1159/000178892.
The functional capacity of the gonadotrophs was assessed by repeated stimulation with small doses of LH-RH (5 microgram intravenously at 2-hour intervals for 3 injections) in normal women during the early and late follicular phases of the menstrual cycle. The results were compared to those obtained when a single dose (100 microgram) of the neurohormone was administered. During the early follicular phase, the release of LH and FSH remained about equal after the 3 successive injections of the small and after the large dose of LH-RH. During the late follicular phase, the release of LH and fsh increased progressively after the repeated administration of the 5 microgram of the neurohormone while the large dose induced a more pronounced and a more sustained pituitary response. This hypersensitivity of the gonadotrophs is observed when the E2 concentrations are higher than in the early follicular phase of the menstrual cycle.
在月经周期的卵泡早期和晚期，通过对正常女性小剂量促黄体激素释放激素（LH-RH）进行反复刺激（每2小时静脉注射5微克，共注射3次）来评估促性腺细胞的功能能力。将结果与单次注射（100微克）该神经激素时获得的结果进行比较。在卵泡早期，小剂量和大剂量LH-RH连续3次注射后，促黄体生成素（LH）和促卵泡生成素（FSH）的释放量大致相等。在卵泡晚期，反复注射5微克神经激素后，LH和FSH的释放量逐渐增加，而大剂量则引起更明显、更持久的垂体反应。当雌二醇（E2）浓度高于月经周期卵泡早期时，会观察到促性腺细胞的这种超敏反应。
