Al-Zubi Mohammad, Al-Shami Khayry, Sawalha Leen, Alguzo Heyam Mahmoud, Al Demour Saddam, Al-Mnayyis Asma'a Mohammad, Alazab Rami, Al-Rawashdah Samer Fathi, Alzoubi Lana Talal, Al-Khawaldeh Sawsan Radi
Department of Surgery, Division of Urology, Yarmouk University MEdical SChool, Irbid, 21110, Jodan.
Department of Clinical Medical Sciences, Yarmouk University Medical school, Irbid, Jordan.
Int J Gen Med. 2024 Apr 23;17:1571-1577. doi: 10.2147/IJGM.S452754. eCollection 2024.
Renal cell carcinoma (RCC) is a type of urological malignancy that affects approximately 2% of the global population. Imaging modalities, especially computed tomography (CT) scanning, play a critical role in diagnosing RCC. In this study, we investigated whether there is a relationship between tumour grade of clear cell RCC and HU values of renal lesions on CT scan performed before operation.
We conducted a retrospective analysis of 123 patients who underwent radical or partial (open or laparoscopic) nephrectomy for clear cell RCC between January 2017 and January 2021. Post-operation histopathological grades were recorded according to World Health Organization (WHO)/International Society of Urological Pathology (ISUP) 2016 grading system and divided into low grade (includes grade 1 and 2) and high grade (grade 3 and 4), and their links to age, sex, smoking habits, tumour size, and HUs of renal lesions were evaluated.
The mean age of the patients studied was 63.02 years old. About 56.9% of the patients were low grade (grade 1 or grade 2), while 43.1% were high grade (grade 3 or 4). The mean tumour size was 6.31 cm. There were no significant differences in tumour grade according to age, sex, or smoking habits. We found a significant relation between tumour grade and HU in the pre-contrast and nephrogenic phases, with p values of 0.001 and 0.037, respectively. On the other hand, there was no significant relation linking the tumour grade to the difference in HU between these phases, where there was a p value of 0.641.
HU in the pre-contrast and nephrogenic phases in addition to tumour size on CT scan have a significant relation to clear cell RCC grade.
肾细胞癌（RCC）是一种泌尿系统恶性肿瘤，全球约2%的人口受其影响。成像方式，尤其是计算机断层扫描（CT）在RCC的诊断中起着关键作用。在本研究中，我们调查了术前CT扫描中肾透明细胞癌的肿瘤分级与肾脏病变的HU值之间是否存在关联。
我们对2017年1月至2021年1月期间因肾透明细胞癌接受根治性或部分（开放或腹腔镜）肾切除术的123例患者进行了回顾性分析。根据世界卫生组织（WHO）/国际泌尿病理学会（ISUP）2016分级系统记录术后组织病理学分级，并分为低级别（包括1级和2级）和高级别（3级和4级），并评估其与年龄、性别、吸烟习惯、肿瘤大小以及肾脏病变HU值的关联。
研究患者的平均年龄为63.02岁。约56.9%的患者为低级别（1级或2级），而43.1%为高级别（3级或4级）。平均肿瘤大小为6.31厘米。根据年龄、性别或吸烟习惯，肿瘤分级无显著差异。我们发现肿瘤分级与平扫期和肾皮质期的HU之间存在显著关联，p值分别为0.001和0.037。另一方面，肿瘤分级与这些阶段之间HU的差异无显著关联，p值为0.641。
CT扫描平扫期和肾皮质期的HU以及肿瘤大小与肾透明细胞癌分级有显著关联。
