pilot study into superficial microcirculatory characteristics of colorectal adenomas using novel high-resolution magnifying endoscopy with blue laser imaging.

BACKGROUND

No studies have yet been conducted on changes in microcirculatory hemodynamics of colorectal adenomas under endoscopy. The microcirculation of the colorectal adenoma could be observed by a novel high-resolution magnification endoscopy with blue laser imaging (BLI), thus providing a new insight into the microcirculation of early colon tumors.

AIM

To observe the superficial microcirculation of colorectal adenomas using the novel magnifying colonoscope with BLI and quantitatively analyzed the changes in hemodynamic parameters.

METHODS

From October 2019 to January 2020, 11 patients were screened for colon adenomas with the novel high-resolution magnification endoscope with BLI. Video images were recorded and processed with Adobe Premiere, Adobe Photoshop and Image-pro Plus software. Four microcirculation parameters: Microcirculation vessel density (MVD), mean vessel width (MVW) with width standard deviation (WSD), and blood flow velocity (BFV), were calculated for adenomas and the surrounding normal mucosa.

RESULTS

A total of 16 adenomas were identified. Compared with the normal surrounding mucosa, the superficial vessel density in the adenomas was decreased (MVD: 0.95 ± 0.18 1.17 ± 0.28 μm/μm, < 0.05). MVW (5.11 ± 1.19 4.16 ± 0.76 μm, < 0.05) and WSD (11.94 ± 3.44 9.04 ± 3.74, < 0.05) were both increased. BFV slowed in the adenomas (709.74 ± 213.28 1256.51 ± 383.31 μm/s, < 0.05).

CONCLUSION

The novel high-resolution magnification endoscope with BLI can be used for study of adenoma superficial microcirculation. Superficial vessel density was decreased, more irregular, with slower blood flow.