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私立医院和国民保健服务(NHS)医院择期髋关节和膝关节置换手术的患者预后、效率及不良事件:一项基于英格兰人群的队列研究

Patient outcomes, efficiency, and adverse events for elective hip and knee replacement in private and NHS hospitals: a population-based cohort study in England.

作者信息

Anderson Michael, Friebel Rocco, Maynou Laia, Kyriopoulos Ilias, McGuire Alistair, Mossialos Elias

机构信息

Health Organisation, Policy, Economics (HOPE), Centre for Primary Care & Health Services Research, The University of Manchester, United Kingdom.

LSE Health, Department of Health Policy, London School of Economics and Political Science, London, United Kingdom.

出版信息

Lancet Reg Health Eur. 2024 Apr 17;40:100904. doi: 10.1016/j.lanepe.2024.100904. eCollection 2024 May.

Abstract

BACKGROUND

Since the early 2000s, the National Health Service (NHS) in England has expanded provision of publicly funded care in private hospitals as a strategy to meet growing demand for elective care. This study aims to compare patient outcomes, efficiency and adverse events in private and NHS hospitals when providing elective hip and knee replacement.

METHODS

We conducted a population-based cohort study including patients ≥18 years, undergoing a publicly funded elective hip or knee replacement in private and NHS hospitals in England between January 1st 2016 and March 31st 2019. Comparative probability was estimated for three patient outcome measures (in-hospital mortality, emergency readmissions with 28 days, hospital transfers), two efficiency measures (pre-operative length of stay (LOS) >0 day and post-operative LOS >2 days), and four adverse events (hospital-associated infection, adverse drug reactions, pressure ulcers, venous thromboembolism). Probit regression was used to adjust for observable confounding followed by instrumental variable (IV) analyses to also account for unobserved confounding at the patient-level. Propensity score matching was then used as a robustness check.

FINDINGS

Our study sample included 169,232 patients in private hospitals, and 262,659 patients in NHS hospitals. Estimates from probit regression indicated that treatment in private hospital was associated with reduced probability of in-hospital mortality (-0.0009, 95% CI -0.0010, -0.0007), emergency readmissions (-0.0181, 95% CI -0.0191, -0.0172), hospital transfers (-0.0076, 95% CI -0.0084, -0.0068), prolonged post-operative LOS (-0.1174, 95% CI -0.1547, -0.0801), hospital-associated infection (-0.0115, 95% CI -0.0123, -0.0107), adverse drug reactions (-0.0051, 95% CI -0.0056, -0.0046), pressure ulcers (-0.0017, 95% CI -0.0019, -0.0014), and venous thromboembolism (-0.0027, 95% CI -0.0031, -0.0022). IV analyses produced no significant differences between private and NHS hospitals, except for lower probability in private hospitals of hospital-associated infection (-0.0057, 95% CI -0.0081, -0.0032), and greater probability in private hospitals of prolonged post-operative LOS (0.2653, 95% CI 0.1833, 0.3472). Propensity score matching produced similar results to probit regression.

INTERPRETATION

Our findings indicate there is potentially important unobservable confounding at the patient-level between private and NHS hospitals not adjusted for when using probit regression or propensity score matching.

FUNDING

This research did not receive any dedicated funding.

摘要

背景

自21世纪初以来,英国国家医疗服务体系(NHS)扩大了在私立医院提供公共资金资助护理的规模,以此作为满足择期护理不断增长需求的一项策略。本研究旨在比较私立医院和NHS医院在提供择期髋关节和膝关节置换手术时的患者预后、效率和不良事件。

方法

我们进行了一项基于人群的队列研究,纳入了2016年1月1日至2019年3月31日期间在英格兰私立医院和NHS医院接受公共资金资助的择期髋关节或膝关节置换手术、年龄≥18岁的患者。对三项患者预后指标(住院死亡率、28天内急诊再入院、医院内转院)、两项效率指标(术前住院时间(LOS)>0天和术后LOS>2天)以及四项不良事件(医院相关感染、药物不良反应、压疮、静脉血栓栓塞)进行了比较概率估计。使用概率单位回归对可观察到的混杂因素进行调整,随后进行工具变量(IV)分析,以考虑患者层面未观察到的混杂因素。然后使用倾向得分匹配作为稳健性检验。

研究结果

我们的研究样本包括私立医院的169,232名患者和NHS医院的262,659名患者。概率单位回归估计表明,在私立医院接受治疗与降低住院死亡率(-0.0009,95%置信区间-0.0010,-0.0007)、急诊再入院率(-0.0181,95%置信区间-0.0191,-0.0172)、医院内转院率(-0.0076,95%置信区间-0.0084,-0.0068)、术后住院时间延长(-0.1174,95%置信区间-0.1547,-0.0801)、医院相关感染(-0.0115,95%置信区间-0.0123,-0.0107)、药物不良反应(-0.0051,95%置信区间-0.0056,-0.0046)、压疮(-0.0017,95%置信区间-0.0019,-0.0014)以及静脉血栓栓塞(-0.0027,95%置信区间-0.0031,-0.0022)的概率相关。IV分析显示私立医院和NHS医院之间没有显著差异,只是私立医院发生医院相关感染的概率较低(-0.0057,95%置信区间-0.0081,-0.0032),而私立医院术后住院时间延长的概率较高(0.2653,95%置信区间0.1833,0.3472)。倾向得分匹配产生了与概率单位回归相似的结果。

解读

我们的研究结果表明,在私立医院和NHS医院之间,患者层面可能存在重要的未观察到的混杂因素,在使用概率单位回归或倾向得分匹配时未进行调整。

资金来源

本研究未获得任何专项资助。

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