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大剂量斑蝥素中毒所致多器官功能障碍综合征:一例报告

Multiorgan dysfunction syndrome due to high-dose cantharidin poisoning: A case report.

作者信息

Xu Wan-Ling, Tang Wen-Jing, Yang Wei-Ying, Sun Li-Chao, Zhang Ze-Qun, Li Wei, Zang Xiu-Xian

机构信息

Department of Emergency Medicine, First Hospital of Jilin University, Changchun 130021, Jilin Province, China.

Department of Chinese Traditional Medicine, First Hospital of Jilin University, Changchun 130021, Jilin Province, China.

出版信息

World J Clin Cases. 2024 Apr 26;12(12):2074-2078. doi: 10.12998/wjcc.v12.i12.2074.

Abstract

BACKGROUND

This report delves into the diagnostic and therapeutic journey undertaken by a patient with high-dose cantharidin poisoning and multiorgan dysfunction syndrome (MODS). Particular emphasis is placed on the comprehensive elucidation of the clinical manifestations of high-dose cantharidin poisoning, the intricate path to diagnosis, and the exploration of potential underlying mechanisms.

CASE SUMMARY

A patient taking 10 g of cantharidin powder orally subsequently developed MODS. The patient was treated with supportive care, fluid hydration and antibiotics, and hemoperfusion and hemofiltration therapy for 24 h and successfully recovered 8 d after hospital admission. Cantharidin poisoning can cause life-threatening MODS and is rare clinically. This case underscores the challenge in diagnosis and highlights the need for early clinical differentiation to facilitate accurate assessment and prompt intervention.

CONCLUSION

This article has reported and analyzed the clinical data, diagnosis, treatment, and prognosis of a case of high-dose cantharidin poisoning resulting in MODS and reviewed the relevant literature to improve the clinical understanding of this rare condition.

摘要

背景

本报告深入探讨了一名高剂量斑蝥素中毒并伴有多器官功能障碍综合征(MODS)患者的诊断和治疗过程。特别强调全面阐明高剂量斑蝥素中毒的临床表现、复杂的诊断路径以及对潜在机制的探索。

病例摘要

一名口服10克斑蝥素粉末的患者随后出现了多器官功能障碍综合征。患者接受了支持治疗、液体水化和抗生素治疗,并进行了24小时的血液灌流和血液滤过治疗,入院8天后成功康复。斑蝥素中毒可导致危及生命的多器官功能障碍综合征,临床上较为罕见。该病例凸显了诊断方面的挑战,并强调了早期临床鉴别以促进准确评估和及时干预的必要性。

结论

本文报告并分析了一例因高剂量斑蝥素中毒导致多器官功能障碍综合征的临床资料、诊断、治疗及预后,并复习了相关文献,以提高对这种罕见病症的临床认识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c91/11045515/9802b2d7857e/WJCC-12-2074-g001.jpg

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