Zhang Y Y, Yu Y L, Zhang J, Guan C H, Ren L, Liu L
Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Fa Yi Xue Za Zhi. 2020 Aug;36(4):545-548. doi: 10.12116/j.issn.1004-5619.2020.04.021.
Cantharidin poisoning has been proven to cause multiple organ damage. Acute circulatory failure, acute renal failure, and multiple organ failure resulting from cantharidin poisoning are the main causes of death for patients with cantharidin poisoning. However, research on the damage of main target organs and mechanism of cantharidin poisoning is not clear. This paper reviews the latest toxicological and pathological research literatures at home and abroad related to cantharidin poisoning and comprehensively summarizes the latest research progress on the toxicological and pathological damage and mechanism of the digestive system, circulatory system, respiratory system, urinary system, reproductive system, skin mucosa, immune system, and nervous system after cantharidin poisoning, to provide reference for improving the molecular toxicological mechanism of cantharidin poisoning and decision-making in the clinical intervention of cantharidin poisoning.
斑蝥素中毒已被证实可导致多器官损害。斑蝥素中毒所致的急性循环衰竭、急性肾衰竭和多器官功能衰竭是斑蝥素中毒患者的主要死亡原因。然而,关于斑蝥素中毒主要靶器官的损害及机制的研究尚不清楚。本文综述了国内外与斑蝥素中毒相关的最新毒理学和病理学研究文献,全面总结了斑蝥素中毒后消化系统、循环系统、呼吸系统、泌尿系统、生殖系统、皮肤黏膜、免疫系统和神经系统的毒理学和病理学损害及机制的最新研究进展,为完善斑蝥素中毒的分子毒理学机制及斑蝥素中毒临床干预决策提供参考。