Biological Activity of 6,7-Dehydroxyroyleanone and Derivatives Obtained from (Codd) A.J.Paton.

The genus (Lamiaceae) is known to be rich in abietane diterpenes. The bioactive 6,7-dehydroxyroyleanone (DHR, ) was previously isolated from var. and var. . This study aimed to explore the occurrence of DHR, , in and the potential bioactivities of new semisynthetic derivatives from DHR, . Several extraction methods were evaluated, and the hydrodistillation, using a Clevenger apparatus, afforded the highest yield (77.8 mg/g of in the essential oil). Three new acyl derivatives (-) were successfully prepared from (yields of 86-95%). Compounds - showed antioxidant activity, antibacterial effects, potent cytotoxic activity against several cell lines, and enhanced anti-inflammatory activity that surpassed dexamethasone (positive control). These findings encourage further exploration of derivatives - for potential mechanisms of antitumoral, antioxidant, and anti-inflammatory capabilities, studying both safety and efficacy.