Ndjoubi Kadidiatou O, Sharma Rajan, Badmus Jelili A, Jacobs Ayesha, Jordaan Audrey, Marnewick Jeanine, Warner Digby F, Hussein Ahmed A
Chemistry Department, Cape Peninsula University of Technology, Bellville Campus, Symphony Road, Bellville 7535, South Africa.
Applied Microbial and Health Biotechnology Institute, Cape Peninsula University of Technology, Symphony Road, Bellville 7535, South Africa.
Plants (Basel). 2021 Jan 19;10(1):175. doi: 10.3390/plants10010175.
Medicinal plants of the genus (Lamiaceae) are well known for their ethnomedicinal applications. , which is native to South Africa, is traditionally used in the treatment of respiratory conditions, scabies, and cutaneous wounds. The phytochemical studies of led to the isolation of five known royleanone abietanes, namely, 6β,7α-dihydroxyroyleanone (), 7α-acetoxy-6β-hydroxyroyleanone (), horminone (), coleon U quinone (), and carnosolon (). The relative configuration of compound was established by X-ray analysis. Compounds - showed antimycobacterial activity (Minimum inhibitory concentration for 90% inhibition, MIC = 5.61-179.60 μM) against HRv. Compound and showed comparable toxicity (Concentration for 50% inhibition, IC 98.49 μM and 79.77 μM) to tamoxifen (IC 22.00 μg/mL) against HaCaT cells. Compounds - showed antioxidant activity through single-electron transfer (SET) and/or hydrogen-atom transfer (HAT) with compound being the most active antioxidant agent. Compounds and were isolated for the first time from The observed results suggest as an important ethnomedicinal plant and as a promising source of diterpenoids with potential use in the treatment of tuberculosis and psoriasis.
唇形科植物以其民族药用价值而闻名。原产于南非的[植物名称未给出]，传统上用于治疗呼吸道疾病、疥疮和皮肤伤口。对[植物名称未给出]的植物化学研究导致分离出五种已知的瑞香烷型二萜，即6β,7α - 二羟基瑞香烷酮（[化合物名称未给出]）、7α - 乙酰氧基 - 6β - 羟基瑞香烷酮（[化合物名称未给出]）、霍米酮（[化合物名称未给出]）、结肠素U醌（[化合物名称未给出]）和肉珊瑚素（[化合物名称未给出]）。化合物[具体化合物未明确]的相对构型通过X射线分析确定。化合物[未明确具体化合物范围]对人结核分枝杆菌显示出抗分枝杆菌活性（90%抑制的最低抑菌浓度，MIC = 5.61 - 179.60 μM）。化合物[未明确具体化合物范围]对人永生化表皮角质形成细胞HaCaT细胞显示出与他莫昔芬（IC50 22.00 μg/mL）相当的毒性（50%抑制浓度，IC50分别为98.49 μM和79.77 μM）。化合物[未明确具体化合物范围]通过单电子转移（SET）和/或氢原子转移（HAT）表现出抗氧化活性，其中化合物[最具活性的抗氧化剂未明确具体化合物]是最具活性的抗氧化剂。化合物[未明确具体化合物范围]首次从[植物名称未给出]中分离得到。观察结果表明[植物名称未给出]是一种重要的民族药用植物，也是一种有前途的二萜类化合物来源，在治疗结核病和牛皮癣方面具有潜在用途。
