Bai Ziyang, Zhao Yifan, Cui Chenying, Yan Jingyu, Qin Danlei, Tong Jiahui, Peng Hongyi, Liu Yingyu, Sun Lingxiang, Wu Xiuping, Li Bing, Li Xia
Shanxi Medical University School and Hospital of Stomatology, Taiyuan, Shanxi 030001, China.
Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, Shanxi 030001, China.
ACS Omega. 2024 Apr 12;9(16):17784-17807. doi: 10.1021/acsomega.4c00923. eCollection 2024 Apr 23.
Implant-associated infections and the increasing number of bone implants loosening and falling off after implantation have become urgent global challenges, hence the need for intelligent alternative solutions to combat implant loosening and falling off. The application of polyetheretherketone (PEEK) in biomedical and medical therapy has aroused great interest, especially because its elastic modulus close to bone provides an effective alternative to titanium implants, thereby preventing the possibility of bone implants loosening and falling off due to the mismatch of elastic modulus. In this Review, we provide a comprehensive overview of recent advances in surface modifications to prevent bone binding deficiency and bacterial infection after implantation of bone implants, starting with inorganics for surface modification, followed by organics that can effectively promote bone integration and antimicrobial action. In addition, surface modifications derived from cells and related products of biological activity have been proposed, and there is increasing evidence of clinical potential. Finally, the advantages and future challenges of surface strategies against medical associated poor osseointegration and infection are discussed, with promising prospects for developing novel osseointegration and antimicrobial PEEK materials.
植入相关感染以及植入后骨植入物松动和脱落数量的增加已成为全球紧迫的挑战，因此需要智能替代解决方案来对抗植入物的松动和脱落。聚醚醚酮（PEEK）在生物医学和医学治疗中的应用引起了极大的兴趣，特别是因为其接近骨骼的弹性模量为钛植入物提供了有效的替代方案，从而防止了由于弹性模量不匹配而导致骨植入物松动和脱落的可能性。在本综述中，我们全面概述了为防止骨植入物植入后骨结合不足和细菌感染而进行的表面改性的最新进展，首先介绍用于表面改性的无机物，然后是能够有效促进骨整合和抗菌作用的有机物。此外，还提出了源自细胞和具有生物活性的相关产品的表面改性方法，并且越来越多的证据表明其具有临床潜力。最后，讨论了针对医学相关的骨整合不良和感染的表面策略的优点和未来挑战，开发新型骨整合和抗菌PEEK材料具有广阔前景。
