King's College London, Bush House NE 4.08, 30 Aldwych, WC2B 4BG, London, England.
Institute for Innovation and Public Purpose, University College London, London, England.
Bull World Health Organ. 2024 May 1;102(5):344-351. doi: 10.2471/BLT.24.291388. Epub 2024 Mar 27.
The World Health Organization (WHO) set up the messenger ribonucleic acid (mRNA) technology transfer programme in June 2021 with a development hub in South Africa and 15 partner vaccine producers in middle-income countries. The goal was to support the sustainable development of and access to life-saving vaccines for people in these countries as a means to enhance epidemic preparedness and global public health. This initiative aims to build resilience and strengthen local vaccine research, and development and manufacturing capacity in different regions of the world, especially those areas that could not access coronavirus disease 2019 (COVID-19) vaccines in a timely way. This paper outlines the current global vaccine market and summarizes the findings of a case study on the mRNA technology transfer programme conducted from November 2022 to May 2023. The study was guided by the vision of the WHO Council on the Economics of Health for All to build an economy for health using its four work streams of value, finance, innovation and capacity. Based on the findings of the study, we offer a mission-oriented policy framework to support the mRNA technology transfer programme as a pilot for transformative change towards an ecosystem for health innovation for the common good. Parts of this vision have already been incorporated into the governance of the mRNA technology transfer programme, while other aspects, especially the common good approach, still need to be applied to achieve the goals of the programme.
世界卫生组织（世卫组织）于 2021 年 6 月设立了信使核糖核酸（mRNA）技术转让方案，在南非设立了一个开发中心和 15 个中等收入国家的伙伴疫苗生产商。目标是支持这些国家的可持续发展并获得救命疫苗，以此增强大流行病防范和全球公共卫生。该倡议旨在建立抵御能力，加强世界不同地区的本地疫苗研究、开发和制造能力，特别是那些无法及时获得 2019 年冠状病毒病（COVID-19）疫苗的地区。本文概述了当前全球疫苗市场，并总结了 2022 年 11 月至 2023 年 5 月期间就 mRNA 技术转让方案进行的案例研究结果。该研究以世卫组织全民健康经济理事会的愿景为指导，通过价值、金融、创新和能力四个工作流来建设健康经济。根据研究结果，我们提供了一个以使命为导向的政策框架，以支持 mRNA 技术转让方案作为迈向造福全民的健康创新生态系统的变革性变革的试点。该愿景的部分内容已经纳入了 mRNA 技术转让方案的治理，而其他方面，特别是共同利益方法，仍需要加以应用，以实现该方案的目标。
