Introduction Smartphones are widely utilized by individuals on a daily basis for a variety of activities, including communication, web browsing, and gaming. However, the excessive and prolonged use of these devices often leads to adverse effects on musculoskeletal health. This study aimed to assess the effect of mobile phone use on musculoskeletal complaints among nursing students at Northern Border University. Methods An analytical descriptive study was conducted using a convenience sample of 202 nursing students recruited via a Google survey questionnaire. The questionnaire comprised four sections concerning the students' demographics, smartphone data collection tools, the Smartphone Addiction Scale (SAS-SV), and the Nordic Musculoskeletal Questionnaire (NMQ). Results Among the study participants, 62.6% were females, with 52.4% spending more than 5 hours daily on media and technology usage, often extending into bedtime. In the last 12 months, neck pain was the most prevalent complaint, reported by 38.8% of the participants, followed by shoulder pain experienced by 20.3% of the sample. Notably, female students displayed a significantly higher incidence of musculoskeletal pain, with rates as high as 81.7% showing statistical significance (p<0.001). A significant association was also observed between mobile phone addiction and academic grade, as well as the time spent on media and technology usage daily (p<0.001). Conclusions There is a significant association between mobile phone use and discomfort in the musculoskeletal system, particularly in the neck region. Moreover, female students tend to experience more pronounced musculoskeletal discomfort compared to their male counterparts. The study also suggests that extended usage of mobile phones, especially at bedtime, increases the likelihood of experiencing musculoskeletal discomfort.