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印度一家三级医疗中心镰刀菌病的临床谱——一项回顾性研究。

Clinical spectrum of fusariosis from a tertiary care center in India- a retrospective study.

作者信息

Sudhaharan Sukanya, Pamidimukkala Umabala, Singh Kumari Neha, Chavali Padmasri

机构信息

Department of Microbiology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.

出版信息

Iran J Microbiol. 2024 Feb;16(1):145-150. doi: 10.18502/ijm.v16i1.14884.

Abstract

BACKGROUND AND OBJECTIVES

spp. is an emerging pathogen that presents with varied clinical presentations but there are very few studies from India that elaborate on the spectrum of infection caused by the fungus. Hence, the present study was conducted in our institute to understand the clinical spectrum of fusariosis.

MATERIALS AND METHODS

The present study was a retrospective study conducted at a tertiary care institute, in Hyderabad, Telangana, India for four years from January 2018 to December 2022. All the patients with clinically significant isolation of spp. from various samples were included in the study.

RESULTS

There were 25 cases of fusariosis diagnosed during the study period. was isolated predominantly from debrided tissue following road traffic accidents in 12/25 (84%) of the cases, nails in 3/25 (12%) and superficial leg ulcer in 1/25 (4%) of the cases. Speciation was done for four patients. Three were and one was . The patients were treated surgically and with/without antifungal therapy and were discharged in a stable condition.

CONCLUSION

Traumatic injuries were the major cause of infections in the present study. As is a virulent and highly resistant pathogen, an early suspicion and an appropriate diagnosis would lead to a better outcome in these patients.

摘要

背景与目的

镰孢菌属是一种新兴病原体,临床表现多样,但印度很少有研究详细阐述该真菌引起的感染谱。因此,我们研究所开展了本研究以了解镰刀菌病的临床谱。

材料与方法

本研究是一项回顾性研究,于2018年1月至2022年12月在印度特伦甘纳邦海得拉巴的一家三级医疗机构进行了四年。所有从各种样本中临床分离出具有显著意义的镰孢菌属的患者均纳入研究。

结果

研究期间共诊断出25例镰刀菌病病例。在12/25(84%)的病例中,镰孢菌主要从道路交通事故后的清创组织中分离出,3/25(12%)从指甲中分离出,1/25(4%)从腿部浅表溃疡中分离出。对四名患者进行了菌种鉴定。三例为某菌种,一例为另一菌种。患者接受了手术治疗及有/无抗真菌治疗,出院时病情稳定。

结论

在本研究中,创伤性损伤是感染的主要原因。由于镰孢菌是一种毒性强且高度耐药的病原体,早期怀疑和恰当诊断将使这些患者获得更好的治疗结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d259/11055442/67b5dce1d43a/IJM-16-145-g001.jpg

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