Sinh Preetika, Cross Raymond K
Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, Maryland.
Gastroenterol Hepatol (N Y). 2024 Apr;20(4):204-215.
Patients with inflammatory bowel disease (IBD) have an increased risk of cardiovascular disease (CVD) such as myocardial infarction and stroke. CVD in patients with IBD might occur in those with younger age and active disease, which are not traditional risk factors of CVD. Atherosclerotic CVD (ASCVD) and IBD are both proinflammatory conditions, and the underlying chronic inflammation might drive ASCVD risk. Decreasing inflammation might reduce this risk; however, data are limited. IBD medications can increase or decrease ASCVD risk. There are no specific guidelines or modalities to assess ASCVD in IBD. Early detection and risk stratification strategies have been established in other chronic inflammatory disorders. This article discusses causes of CVD in IBD and strategies to modify the consequences.
炎症性肠病（IBD）患者发生心血管疾病（CVD）如心肌梗死和中风的风险增加。IBD患者的CVD可能发生在较年轻且疾病活动的患者中，而这些并非CVD的传统风险因素。动脉粥样硬化性CVD（ASCVD）和IBD均为促炎性病症，潜在的慢性炎症可能会增加ASCVD风险。减轻炎症可能会降低这种风险；然而，相关数据有限。IBD药物可增加或降低ASCVD风险。目前尚无评估IBD患者ASCVD的具体指南或方法。在其他慢性炎症性疾病中已确立了早期检测和风险分层策略。本文讨论了IBD中CVD的病因以及改善其后果的策略。
