From the Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics, Gynecology, and Reproductive Sciences.
Urogynecology (Phila). 2024 May 1;30(5):519-527. doi: 10.1097/SPV.0000000000001461.
Pelvic floor disorders (PFDs) constitute a major public health issue given their negative effect on quality of life for millions of women worldwide and the associated economic burden. As the prevalence of PFDs continues to increase, novel therapeutic approaches for the effective treatment of these disorders are urgently needed. Regenerative medicine techniques, including cellular therapies, extracellular vesicles, secretomes, platelet-rich plasma, laser therapy, and bioinductive acellular biomaterial scaffolds, are emerging as viable clinical options to counteract urinary and fecal incontinence, as well as pelvic organ prolapse. This brief expert review explores the current state-of-science regarding application of these therapies for the treatment of PFDs. Although regenerative approaches have not been widely deployed in clinical care to date, these innovative techniques show a promising safety profile and potential to positively affect the quality of life of patients with PFDs. Furthermore, investigations focused on regeneration of the main constituents of the pelvic floor and lower urinary tract improve our understanding of the underlying pathophysiology of PFDs. Regenerative medicine techniques have a high potential not only to revolutionize treatment of PFDs but also to prevent these complex conditions.
盆底功能障碍（PFD）是一个主要的公共卫生问题，因为它们会对全球数以百万计的女性的生活质量产生负面影响，并且会带来相关的经济负担。随着 PFD 的患病率持续上升，迫切需要新的治疗方法来有效治疗这些疾病。再生医学技术，包括细胞疗法、细胞外囊泡、分泌组、富含血小板的血浆、激光治疗和生物诱导的去细胞生物材料支架，作为治疗尿失禁和粪失禁以及盆腔器官脱垂的可行临床选择正在出现。这篇简要的专家综述探讨了这些疗法在治疗 PFD 中的应用的当前科学状况。尽管到目前为止，再生方法尚未广泛应用于临床护理，但这些创新技术显示出良好的安全性和潜在的积极影响，可以改善 PFD 患者的生活质量。此外，专注于盆底和下尿路主要成分再生的研究提高了我们对 PFD 潜在病理生理学的理解。再生医学技术不仅有潜力彻底改变 PFD 的治疗方法，还有潜力预防这些复杂疾病。
