Department of Pharmacology, Central University of Punjab, Bathinda, 151401, India.
Mol Biol Rep. 2024 Apr 29;51(1):586. doi: 10.1007/s11033-024-09520-7.
Parkinson's disease (PD) is a complex and debilitating neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra. The pathogenesis of PD is intimately linked to the roles of two key molecular players, α-synuclein (α-syn) and Parkin. Understanding the intricate interplay between α-syn and Parkin is essential for unravelling the molecular underpinnings of PD. Their roles in synaptic function and protein quality control underscore their significance in neuronal health. Dysregulation of these processes, as seen in PD, highlights the potential for targeted therapeutic strategies aimed at restoring normal protein homeostasis and mitigating neurodegeneration. Investigating the connections between α-syn, Parkin, and various pathological mechanisms provides insights into the complex web of factors contributing to PD pathogenesis and offers hope for the development of more effective treatments for this devastating neurological disorder. The present compilation provides an overview of their structures, regional and cellular locations, associations, physiological functions, and pathological roles in the context of PD.
帕金森病（PD）是一种复杂且使人虚弱的神经退行性疾病，其特征是黑质中多巴胺能神经元的进行性丧失。PD 的发病机制与两个关键分子参与者的作用密切相关，即α-突触核蛋白（α-syn）和 Parkin。理解 α-syn 和 Parkin 之间的复杂相互作用对于揭示 PD 的分子基础至关重要。它们在突触功能和蛋白质质量控制中的作用突出了它们在神经元健康中的重要性。这些过程的失调，如 PD 中所见，强调了针对恢复正常蛋白质动态平衡和减轻神经退行性变的靶向治疗策略的潜力。研究 α-syn、Parkin 和各种病理机制之间的联系，为 PD 发病机制中涉及的复杂因素提供了深入了解，并为开发这种破坏性神经疾病的更有效治疗方法带来了希望。本综述概述了它们在 PD 背景下的结构、区域和细胞定位、关联、生理功能和病理作用。
