维生素 D 状态对川崎病发生的影响：一项荟萃分析。
The effect of vitamin D status on the occurrence of Kawasaki Disease: a meta-analysis.
机构信息
Shaanxi Provincial Key Laboratory of Infection and Immune Diseases, Shaanxi Provincial People's Hospital, 256# Youyi West Road, Xi'an, Shaanxi, 710068, China.
Shaanxi Engineering Research Center of Cell Immunology, Shaanxi Provincial People's Hospital, Xi'an, 710068, China.
出版信息
BMC Pediatr. 2024 Apr 29;24(1):287. doi: 10.1186/s12887-024-04768-1.
AIM
The relationship between vitamin D status and Kawasaki Disease (KD), as well as coronary artery lesion (CAL), has yet to be established.
METHODS
A meta-analysis was conducted to assess the correlation between vitamin D status and KD, as well as the impact of vitamin D status on the progression of KD into CAL.
RESULTS
The meta-analysis revealed a consistent and significant association between serum 25(OH)D level and the occurrence KD (studies N = 22; z = -3.51, P < 0.001). Patients with KD had markedly lower levels of vitamin D than healthy controls (SMD: -1.30 ng/mL, 95%CI: -2.05 to -0.55 ng/mL).
CONCLUSION
The study provided evidence supporting a significant association between lower serum vitamin D levels and the occurrence of KD, particularly within the Chinese population. However, the findings did not suggest a direct impact of vitamin D on the development of CAL in KD patients.
目的
维生素 D 状态与川崎病（KD）以及冠状动脉损伤（CAL）之间的关系尚未确定。
方法
进行荟萃分析以评估维生素 D 状态与 KD 之间的相关性，以及维生素 D 状态对 KD 进展为 CAL 的影响。
结果
荟萃分析显示血清 25（OH）D 水平与 KD 发生之间存在一致且显著的关联（研究 N=22；z=-3.51，P<0.001）。KD 患者的维生素 D 水平明显低于健康对照组（SMD：-1.30ng/mL，95%CI：-2.05 至-0.55ng/mL）。
结论
该研究提供了证据支持血清维生素 D 水平较低与 KD 发生之间存在显著关联，特别是在中国人群中。然而，这些发现并未表明维生素 D 对 KD 患者 CAL 发展的直接影响。
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