Chen Jingjing, Liu Yali, Liu Wenhua, Wu Zubo
Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Department of Epidemiology and Health Statistics, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
J Huazhong Univ Sci Technolog Med Sci. 2011 Oct;31(5):705. doi: 10.1007/s11596-011-0587-9. Epub 2011 Oct 25.
The biomarkers associated with coronary artery lesions (CAL) secondary to Kawasaki disease (KD) in Chinese children were investigated by using Meta-analysis. We searched documents published from January 1997 to December 2009 from medical electronic databases. According to inclusion and exclusion criteria, eligible full-text papers were identified. We conducted a comprehensive quantitative analysis by using Stata10.0 statistical software package to assess the heterogeneity among the documents, calculated the summary effect and analyze publication bias and sensitivity. A total of 92 documents and 16 biomarkers were identified. All documents were case-control studies, and included 2398 patients in CAL group and 5932 patients in non-CAL (NCAL) group. The Meta-analysis showed that the levels of platelet count, platelet hematocrit (PCT), neutrophils count, platelet distribution width (PDW), mean platelet volume (MPV), erythrocyte sedimentation rate (ESR), cardiac troponin I (cTnI), and endothelin-1 (ET-1) in CAL group were significantly higher than those in NCAL group, and serum albumin (Alb) and hemoglobin (Hb) levels were significantly lower in CAL group (all P<0.05). White blood cell (WBC) count, serum sodium, matrix metalloproteinase 9 (MMP-9), total cholesterol (TC), hematocrit (HCT) and CD3+T lymphocytes percentage had no statistically significant difference between the two groups. In conclusion, our results indicated that the 10 biomarkers including platelet count, neutrophils count, PCT, PDW, MPV, ESR, cTnI, ET-1, Alb and Hb were associated with CAL, and may be involved in the pathogenesis of CAL. The biomarkers of WBC count, serum sodium, MMP-9, TC, HCT, and CD3+T lymphocytes percentage bore no relationship with the development of CAL among Chinese children with KD.
通过Meta分析研究中国儿童川崎病（KD）继发冠状动脉病变（CAL）相关的生物标志物。我们检索了1997年1月至2009年12月期间医学电子数据库中发表的文献。根据纳入和排除标准，筛选出符合条件的全文论文。使用Stata10.0统计软件包进行全面的定量分析，以评估文献间的异质性，计算汇总效应并分析发表偏倚和敏感性。共识别出92篇文献和16种生物标志物。所有文献均为病例对照研究，CAL组纳入2398例患者，非CAL（NCAL）组纳入5932例患者。Meta分析显示，CAL组的血小板计数、血小板压积（PCT）、中性粒细胞计数、血小板分布宽度（PDW）、平均血小板体积（MPV）、红细胞沉降率（ESR）、心肌肌钙蛋白I（cTnI）和内皮素-1（ET-1）水平显著高于NCAL组，而CAL组的血清白蛋白（Alb）和血红蛋白（Hb）水平显著低于NCAL组（均P<0.05）。两组间白细胞（WBC）计数、血清钠、基质金属蛋白酶9（MMP-9）、总胆固醇（TC）、血细胞比容（HCT）和CD3+T淋巴细胞百分比无统计学显著差异。总之，我们的结果表明，包括血小板计数、中性粒细胞计数、PCT、PDW、MPV、ESR、cTnI、ET-1、Alb和Hb在内的10种生物标志物与CAL相关，可能参与CAL的发病机制。在中国KD儿童中，WBC计数、血清钠、MMP-9、TC、HCT和CD3+T淋巴细胞百分比这些生物标志物与CAL的发生无关。
