Speech Terapist and Epidemiologist Universidade de Pernambuco Santo Amaro- Recife- Pernambuco, Street Arnóbio Marques, Recife, 31050100-130, Brazil.
Universidade de Pernambuco, Recife, Pernambuco, Brazil.
BMC Pediatr. 2024 Apr 29;24(1):286. doi: 10.1186/s12887-024-04728-9.
To describe the feeding characteristics and growth of children with prenatal exposure to Zika virus (ZIKV) from birth to 48 months.
Using data from the prospective Microcephaly Epidemic Research Group Pediatric Cohort (MERG-PC), children without microcephaly born to mothers with evidence of ZIKV infection during pregnancy (ZIKV-exposed children without microcephaly) and children with Zika-related microcephaly were compared using repeated cross-sectional analyses within the following age strata: birth; 1 to 12; 13 to 24; 25 to 36; and 37 to 48 months. The groups were compared in relation to prematurity, birth weight, breastfeeding, alternative feeding routes, dysphagia and anthropometric profiles based on the World Health Organization Anthro z-scores (weight-length/height, weight-age, length/height-age and BMI-age).
The first assessment included 248 children, 77 (31.05%) with microcephaly and 171 (68.95%) without microcephaly. The final assessment was performed on 86 children. Prematurity was 2.35 times higher and low birth weight was 3.49 times higher in children with microcephaly. The frequency of breastfeeding was high (> 80%) in both groups. On discharge from the maternity hospital, the frequency of children requiring alternative feeding route in both groups was less than 5%. After 12 months of age, children with microcephaly required alternative feeding route more often than children without microcephaly. In children with microcephaly, the z-score of all growth indicators was lower than in children without microcephaly.
Children with Zika-related microcephaly were more frequently premature and low birth weight and remained with nutritional parameters, i.e., weight-for-age, weight-for-length/height and length/height-for-age below those of the children without microcephaly.
描述产前暴露于寨卡病毒（ZIKV）的儿童从出生到 48 个月的喂养特征和生长情况。
利用前瞻性小头畸形流行研究组儿科队列（MERG-PC）的数据，对母亲在妊娠期间有 ZIKV 感染证据而无小头畸形的儿童（无小头畸形的 ZIKV 暴露儿童）和有寨卡相关小头畸形的儿童进行比较，采用重复横断面分析方法，分为以下年龄组：出生；1 至 12 个月；13 至 24 个月；25 至 36 个月；37 至 48 个月。根据世界卫生组织 Anthro z 评分（体重-长度/身高、体重-年龄、长度/身高-年龄和 BMI-年龄），比较两组儿童在早产、出生体重、母乳喂养、替代喂养途径、吞咽困难和人体测量特征方面的差异。
第一次评估包括 248 名儿童，其中 77 名（31.05%）患有小头畸形，171 名（68.95%）无小头畸形。最终评估纳入 86 名儿童。患有小头畸形的儿童早产率高出 2.35 倍，出生体重低的比例高出 3.49 倍。两组儿童母乳喂养率均较高（>80%）。从妇产科医院出院时，两组儿童中需要替代喂养途径的频率均低于 5%。12 个月后，患有小头畸形的儿童比无小头畸形的儿童更频繁地需要替代喂养途径。患有小头畸形的儿童的所有生长指标的 z 评分均低于无小头畸形的儿童。
与寨卡相关的小头畸形儿童更常出现早产和低出生体重，且体重-年龄、体重-长度/身高和长度/身高-年龄等营养参数仍低于无小头畸形的儿童。
