Instituto Fernandes Figueira/Instituto Nacional de Infectologia - Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil.
Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
Sci Rep. 2019 Dec 16;9(1):19198. doi: 10.1038/s41598-019-55598-6.
The implications of Zika Virus exposure in pregnancy for early infant growth remains poorly described. The main goal of this study is to compare the growth, body composition, and feeding modality of infants in the first three months of life by prenatal Zika Virus exposure status. We selected an analytical cohort of 115 infants born without microcephaly, comprising 56 infants with qRT-PCR confirmed exposure to ZIKV during gestation and 59 infants born to women with presumptively no evidence of ZIKV in pregnancy. Infants were evaluated at birth, 1 and 3 months of age in terms of anthropometrics, body composition All the results were adjusted by maternal age, maternal BMI and gestational age. We observe no differences between anthropometric measurements at birth. Mothers in exposed group showed higher BMI. At 1 month and 3 months of age there were differences in mid arm circumference, arm muscle circumference and fat free mass. Weight and length was less in the ZIKV exposed in pregnancy infants and statistically different at 3 month of age. The findings of this investigation provide new evidence that ZIKV exposure in pregnancy may be associated with differences in body composition.
妊娠期寨卡病毒暴露对婴儿早期生长的影响仍描述不清。本研究的主要目的是比较产前寨卡病毒暴露状态下婴儿在生命最初三个月的生长、身体成分和喂养方式。我们选择了一个无小头畸形的 115 例婴儿的分析队列，其中 56 例婴儿经 qRT-PCR 确认为妊娠期寨卡病毒暴露，59 例婴儿的母亲在妊娠期间推测无寨卡病毒证据。在出生时、1 个月和 3 个月时，对婴儿进行了人体测量学、身体成分所有结果均按母亲年龄、母亲 BMI 和孕龄进行调整。我们在出生时的人体测量值上没有观察到差异。暴露组的母亲 BMI 较高。在 1 个月和 3 个月时，上臂围、臂肌围和去脂体重存在差异。在妊娠期间暴露于寨卡病毒的婴儿体重和长度较低，在 3 个月时的差异具有统计学意义。本研究的结果提供了新的证据，表明妊娠期寨卡病毒暴露可能与身体成分的差异有关。
