Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
The Collaborative Innovation Center of Tissue Damage Repair and Regenerative Medicine of Zunyi Medical University, Zunyi, China.
J Cell Mol Med. 2024 May;28(9):e18320. doi: 10.1111/jcmm.18320.
Liver diseases include all types of viral hepatitis, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), cirrhosis, liver failure (LF) and hepatocellular carcinoma (HCC). Liver disease is now one of the leading causes of disease and death worldwide, which compels us to better understand the mechanisms involved in the development of liver diseases. Anoctamin 1 (ANO1), a calcium-activated chloride channel (CaCC), plays an important role in epithelial cell secretion, proliferation and migration. ANO1 plays a key role in transcriptional regulation as well as in many signalling pathways. It is involved in the genesis, development, progression and/or metastasis of several tumours and other diseases including liver diseases. This paper reviews the role and molecular mechanisms of ANO1 in the development of various liver diseases, aiming to provide a reference for further research on the role of ANO1 in liver diseases and to contribute to the improvement of therapeutic strategies for liver diseases by regulating ANO1.
肝脏疾病包括所有类型的病毒性肝炎、酒精性肝病（ALD）、非酒精性脂肪性肝病（NAFLD）、肝硬化、肝衰竭（LF）和肝细胞癌（HCC）。肝脏疾病目前是全球疾病和死亡的主要原因之一，这促使我们更好地了解肝脏疾病发展中涉及的机制。钙激活氯离子通道（CaCC）ANO1 在上皮细胞分泌、增殖和迁移中发挥重要作用。ANO1 在转录调控以及许多信号通路中发挥关键作用。它参与了几种肿瘤和其他疾病（包括肝脏疾病）的发生、发展、进展和/或转移。本文综述了 ANO1 在各种肝脏疾病发展中的作用和分子机制，旨在为进一步研究 ANO1 在肝脏疾病中的作用提供参考，并通过调节 ANO1 为改善肝脏疾病的治疗策略做出贡献。
