Department of Gastroenterology, Qingdao Sixth People's Hospital, Qingdao, 266001, China.
Department of Endocrinology, Affiliated Qingdao Third People's Hospital, Qingdao University, Qingdao, 266001, China.
J Cancer Res Clin Oncol. 2022 Aug;148(8):2045-2068. doi: 10.1007/s00432-022-04004-2. Epub 2022 Apr 26.
Dysregulation of gene amplification, cell-signaling-pathway transduction, epigenetic and transcriptional regulation, and protein interactions drives tumor-cell proliferation and invasion, while ion channels also play an important role in the generation and development of tumor cells. Overexpression of Ca-activated Cl- channel anoctamin 1 (ANO1) is shown in numerous cancer types and correlates with poor prognosis. However, the mechanisms involved in ANO1-mediated malignant cellular transformation and the role of ANO1 in tumor immunity remain unknown. In this review, we discuss recent studies to determine the role of ANO1 in tumorigenesis and provide novel insights into the role of ANO1 in the context of tumor immunity. Furthermore, we analyze the roles and potential mechanisms of ANO1 in different types of cancers, and provide novel notions for the role of ANO1 in the tumor microenvironment and for potential use of ANO1 in clinical applications. Our review shows that ANO1 is involved in tumor immunity and microenvironment, and may, therefore, be an effective biomarker and therapeutic drug target.
基因扩增、细胞信号转导、表观遗传和转录调控以及蛋白质相互作用的失调驱动肿瘤细胞的增殖和侵袭，而离子通道在肿瘤细胞的发生和发展中也起着重要作用。钙激活氯离子通道 anoctamin 1（ANO1）在许多癌症类型中过度表达，并与预后不良相关。然而，ANO1 介导的恶性细胞转化的机制以及 ANO1 在肿瘤免疫中的作用仍不清楚。在这篇综述中，我们讨论了最近的研究，以确定 ANO1 在肿瘤发生中的作用，并为 ANO1 在肿瘤免疫背景下的作用提供新的见解。此外，我们分析了 ANO1 在不同类型癌症中的作用和潜在机制，并为 ANO1 在肿瘤微环境中的作用以及 ANO1 在临床应用中的潜在用途提供了新的概念。我们的综述表明，ANO1 参与肿瘤免疫和微环境，因此可能是一种有效的生物标志物和治疗药物靶点。
