Gastroenterology, Qilu Hospital of Shandong University, china.
Rev Esp Enferm Dig. 2024 Aug;116(8):416-422. doi: 10.17235/reed.2024.10353/2024.
liver stiffness measurement, assessed by vibration-controlled transient elastography, has been recognized as a powerful tool for liver fibrosis assessment. The potential of liver stiffness measurement to predict clinically relevant outcomes in fatty liver disease has received considerable attention. This study aimed to investigate the prediction of liver-related events in metabolic dysfunction-associated steatotic liver disease patients by liver stiffness measurement value on transient elastography.
the electronic databases including PubMed, EMBASE, Cochrane Library, and ClinicalTrials.gov until 6 September 2023 were systematically searched. The hazard ratios adjusted for confounders were extracted and pooled by random-effects model analysis.
a total of 20,587 individuals from seven studies were included. The pooled hazard ratios (HRs) were 18.65 (95 % CI: 9.95-34.95, p < 0.01, I2 = 0 %) in the stratification analysis of the highest versus lowest liver stiffness measurement categories. In 1-kPa analysis, the risk of liver-related events was increased with 1 kPa increment (HR 1.05, 95 % CI: 1.03-1.07, p < 0.01, I2 = 74.47 %).
metabolic dysfunction-associated steatotic liver disease patients with high liver stiffness measurement values were at an increased risk of liver-related events. Liver stiffness measurement can be used as a prognostic tool to achieve risk stratification in fatty liver patients.
通过振动控制瞬时弹性成像评估的肝硬度测量已被认为是评估肝纤维化的有力工具。肝硬度测量预测脂肪性肝病患者临床相关结局的潜力受到了广泛关注。本研究旨在通过瞬时弹性成像研究肝硬度测量值对代谢相关脂肪性肝病患者肝相关事件的预测作用。
系统检索了截至 2023 年 9 月 6 日的 PubMed、EMBASE、Cochrane 图书馆和 ClinicalTrials.gov 等电子数据库。采用随机效应模型分析提取并汇总校正混杂因素后的风险比。
共有来自 7 项研究的 20587 人纳入本研究。在最高与最低肝硬度测量类别分层分析中，汇总风险比（HR）为 18.65（95%CI：9.95-34.95，p<0.01，I2=0%）。在 1-kPa 分析中，肝相关事件的风险随 1kPa 增加而增加（HR 1.05，95%CI：1.03-1.07，p<0.01，I2=74.47%）。
肝硬度测量值较高的代谢相关脂肪性肝病患者发生肝相关事件的风险增加。肝硬度测量可作为一种预后工具，对脂肪性肝病患者进行风险分层。
