Forsah Sabastain F, Ugwendum Derek, Arrey Agbor Divine Besong, Ndema Nancelle, Ndemazie Nkafu Bechem, Kankeu Tonpouwo Gauvain, Taylor Akua Aboah A, Fuoching Nkeng, James-Gregory Davene, Amoah Shannia, Arulthasan Vaithilingam, Nfonoyim Jay
Internal Medicine, Richmond University Medical Center, Staten Island, USA.
Pulmonary and Critical Care, Richmond University Medical Center, Staten Island, USA.
Cureus. 2024 Mar 30;16(3):e57249. doi: 10.7759/cureus.57249. eCollection 2024 Mar.
Syncope is the transient loss of consciousness due to cerebral hypoperfusion. A significant number of individuals experience a syncopal attack at one stage of their lives. The common causes of syncope include vasovagal syncope, orthostatic hypotension, and cardiac causes. Drugs are also associated with causing syncope. The drugs involved are mostly those that depress the central nervous system, and concomitant use of more than one of such drugs increases the risk of syncope even further. Tizanidine and alcohol individually can cause hypotension and combining both drugs is not advised due to heightened central nervous system depression and profound hypotension. We present a case of a 53-year-old female with alcohol use disorder who presented with a first-time syncopal attack due to postural hypotension after ingesting both tizanidine and alcohol concurrently. Co-administration of tizanidine and alcohol is not advised, however, cases of syncope have been rarely reported with concomitant use. This case will enlighten physicians to counsel patients about the need to abstain from alcohol consumption when taking tizanidine.
晕厥是由于脑灌注不足导致的短暂意识丧失。相当多的人在生命的某个阶段会经历一次晕厥发作。晕厥的常见原因包括血管迷走性晕厥、体位性低血压和心脏原因。药物也与晕厥的发生有关。所涉及的药物大多是那些抑制中枢神经系统的药物，同时使用多种此类药物会进一步增加晕厥的风险。替扎尼定和酒精单独使用均可导致低血压，由于中枢神经系统抑制增强和严重低血压，不建议同时使用这两种药物。我们报告一例53岁患有酒精使用障碍的女性，她在同时摄入替扎尼定和酒精后因体位性低血压首次出现晕厥发作。虽然不建议同时使用替扎尼定和酒精，但同时使用导致晕厥的病例鲜有报道。该病例将提醒医生建议患者在服用替扎尼定时戒酒。
