Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA.
Norton College of Medicine, SUNY Upstate Medical University, Syracuse, New York, USA.
J Child Adolesc Psychopharmacol. 2024 May;34(4):167-182. doi: 10.1089/cap.2024.0022. Epub 2024 Apr 30.
This review aims to present recent innovations and advancements in attention-deficit/hyperactivity disorder (ADHD) care, encompassing international consensus statement, new medication formulations, digital therapeutics, and neurostimulation devices. A comprehensive literature search of relevant articles published in the past five years was conducted, emphasizing the evidence base, efficacy, safety, and practical implications of these advancements. The World Federation of ADHD Consensus Statement offers an updated diagnostic and treatment framework rooted in global scientific evidence. There are several newer ADHD medication formulations, including a nonstimulant (Viloxazine extended release) and the first transdermal amphetamine patch approved to treat ADHD. These options offer some unique benefits to personalize treatment based on symptom profile, lifestyle, preferences, and response. Digital tools offer additional means to restructure environments for individuals with ADHD, reducing impairment and reliance on others. In addition, digital therapeutics enhance access, affordability, personalization, and feasibility of ADHD care, complementing or augmenting existing interventions. Trigeminal nerve stimulation emerges as a well-tolerated nonpharmacological, device-based treatment for pediatric ADHD, with initial trials indicating effect sizes comparable to nonstimulant medications. These innovations in ADHD care represent clinically significant new treatment options and opportunities for personalized care. Health care professionals should integrate these developments into clinical practice, mindful of individual patient and family needs and preferences. Future research should assess long-term outcomes, cost-effectiveness, and acceptability of these innovations.
这篇综述旨在介绍注意力缺陷多动障碍(ADHD)治疗领域的最新创新和进展,包括国际共识声明、新的药物配方、数字疗法和神经刺激设备。对过去五年发表的相关文章进行了全面的文献检索,重点关注这些进展的证据基础、疗效、安全性和实际意义。世界ADHD 共识声明提供了一个基于全球科学证据的更新的诊断和治疗框架。目前有几种新的 ADHD 药物配方,包括一种非兴奋剂(Viloxazine 缓释剂)和第一种经皮安非他命贴片,被批准用于治疗 ADHD。这些选择为根据症状谱、生活方式、偏好和反应来个性化治疗提供了一些独特的优势。数字工具为 ADHD 患者提供了更多的环境重构方法,减少了对他人的依赖和损伤。此外,数字疗法提高了 ADHD 治疗的可及性、可负担性、个性化和可行性,补充或增强了现有的干预措施。三叉神经刺激作为一种耐受性良好的非药物、基于设备的治疗小儿 ADHD 的方法,初步试验表明其疗效与非兴奋剂药物相当。这些 ADHD 治疗领域的创新代表了具有临床意义的新治疗选择和个性化治疗的机会。医疗保健专业人员应将这些发展纳入临床实践,考虑到个体患者和家庭的需求和偏好。未来的研究应评估这些创新的长期结果、成本效益和可接受性。