Auriol M, Beaufils H, Herreman G, Tranbaloc P, Wechsler B, Godeau P, Chomette G
Ann Med Interne (Paris). 1979;130(8-9):393-9.
Full renal investigation were conducted in 11 patients with Behçet's syndrome. Biological tests revealed the presence of mild proteinuria in 5 of them. Needle biopsy showed extra-membranous or mesangial fibrinoid deposits in 6 cases, associated in 1 case with segmental and focal glomerulitis lesions. Immunofluorescence studies demonstrated glomerular deposits of mesangial and extra-membranous C3, sometimes with immunoglobulins (IgA-AgG). Ultrastructural examination was carried out in 7 cases and showed "hump" deposits attached to the external face of the basal membrane and rounded nodules of 7 to 15 mu included in the mesangium. The presence of immune complexes in the renal glomeruli, therefore, is not all unusual in this disease, which is probably auto-immune in nature, and in fact appears to be a quite frequent occurrence. These deposits, which were probably well-tolerated by most of the patients in this series, might be involved in the production of progressive glomerulopathies in chronic cases, as observed in one of the cases studied.
对11例白塞病患者进行了全面的肾脏检查。生物学检查发现其中5例存在轻度蛋白尿。肾穿刺活检显示6例有膜外或系膜纤维蛋白样沉积，1例伴有节段性和局灶性肾小球炎病变。免疫荧光研究显示系膜和膜外C3的肾小球沉积，有时伴有免疫球蛋白（IgA - IgG）。7例进行了超微结构检查，显示“驼峰”样沉积物附着于基底膜外表面，系膜内有7至15微米的圆形结节。因此，肾小球中免疫复合物的存在在这种可能本质上是自身免疫性的疾病中并非不常见，实际上似乎相当常见。这些沉积物在本系列的大多数患者中可能耐受性良好，但正如在所研究的其中1例中观察到的那样，在慢性病例中可能与进行性肾小球病的发生有关。
