El Ramahi K M, Al Dalaan A, Al Shaikh A, Al Meshari K, Akhtar M
Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
J Rheumatol. 1998 Nov;25(11):2254-60.
We describe clinical data on 9 patients with Behçet's disease with renal involvement (8 males, one female) and results of kidney biopsies in 4 patients. Renal involvement occurred in 9 of 120 patients (7.5%) followed at our center. Proteinuria was present in 8 patients (6 with quantitative 24 h urine protein with a range of 0.32-3.11 g/day, mean 1.7 g/day); hematuria occurred in one patient. Impaired renal function was encountered in 2 patients at presentation and in another patient at a later date. Major vascular involvement (major venous and/or arterial thrombosis) was present in 4 patients and sagittal sinus thrombosis in another patient. Measurement of complement C3, C4, and CH50 and immunologic tests for anticardiolipin, antineutrophil cytoplasmic, and antistreptococcal antibodies did not indicate a clear association with renal involvement. Kidney biopsies were performed in 4 patients. Mesangial proliferative changes were observed in 3 patients and evidence of immune complex deposition by immunofluorescence and electron microscopic examination was present in 2 patients. Amyloidosis was present in one patient who had vascular involvement and presented with nephrotic range proteinuria.
我们描述了9例患有贝赫切特病且有肾脏受累的患者（8例男性，1例女性）的临床资料以及4例患者的肾脏活检结果。在我们中心随访的120例患者中，有9例（7.5%）出现肾脏受累。8例患者存在蛋白尿（6例进行了24小时尿蛋白定量，范围为0.32 - 3.11克/天，平均1.7克/天）；1例患者出现血尿。2例患者在就诊时出现肾功能损害，另1例患者在之后出现肾功能损害。4例患者存在主要血管受累（主要静脉和/或动脉血栓形成），另1例患者出现矢状窦血栓形成。补体C3、C4和CH50的检测以及抗心磷脂、抗中性粒细胞胞浆和抗链球菌抗体的免疫学检测均未显示与肾脏受累有明确关联。4例患者进行了肾脏活检。3例患者观察到系膜增生性改变，2例患者通过免疫荧光和电子显微镜检查发现免疫复合物沉积证据。1例有血管受累且出现肾病范围蛋白尿的患者存在淀粉样变性。
