支气管哮喘中血管紧张素转换酶的动脉水平与动脉血气张力之间的关系。

The relationship between the arterial level of angiotensin-converting enzymes and arterial gas tension in bronchial asthma.

作者信息

Mue S, Takahashi M, Ohmi T, Okayama H, Shibahara S, Yamauchi K, Fujimoto S, Tamura G, Takishima T

出版信息

Ann Allergy. 1979 Sep;43(3):179-86.

Abstract

To study the mechanism which causes a lowered serum level of angiotensin-converting enzyme (ACE) in asthma patients, the changes in serum ACE in arterial blood gas tension was measured. Serum ACE was also determined in patients with chronic obstructive lung disease (COLD) and fibrosing lung disease (FLD). A reduced level of serum ACE was found in some patients with COLD, similar to that in patients with asthma. A significant relationship existed between the lowered serum ACE level and the degree of arterial hypoxia, especially in asthmatic patients and some patients with COLD. The significance of lowered serum ACE is discussed in relation to the pathogenesis and the mechanism of hypoxemia in patients with asthma, COLD and FLD.

摘要

为研究导致哮喘患者血清血管紧张素转换酶（ACE）水平降低的机制，对动脉血气张力变化时血清ACE的变化进行了测量。还对慢性阻塞性肺疾病（COLD）和肺纤维化疾病（FLD）患者的血清ACE进行了测定。在一些COLD患者中发现血清ACE水平降低，与哮喘患者相似。血清ACE水平降低与动脉缺氧程度之间存在显著关系，尤其是在哮喘患者和一些COLD患者中。结合哮喘、COLD和FLD患者的发病机制及低氧血症机制对血清ACE降低的意义进行了讨论。