Son Moonil
Department of Microbiology, Pusan National University, Busan, Korea.
Microbiological Resource Research Institute, Pusan National University, Busan, Korea.
Mycobiology. 2024 Mar 9;52(2):85-91. doi: 10.1080/12298093.2024.2322211. eCollection 2024.
In filamentous fungi, vegetative cell fusion occurs within and between individuals. These fusions of growing hyphae (anastomosis) from two individuals produce binucleated cells with mixed cytoplasm known as heterokaryons. The fate of heterokaryotic cells was genetically controlled with delicacy by specific loci named (heterokaryon) or (vegetative incompatibility) as a part of self-/nonself-recognition system. When loci of two individuals are incompatible, the resulting heterokaryotic cells underwent programmed cell death or showed severely impaired fungal growth. In , - is one of at least nine alleles that control heterokaryon incompatibility and the altered protein conformation [Het-s] prion. The present study describes the [Het-s] prion in terms of (1) the historical discovery based on early genetic and physiological studies, (2) architecture built on its common and unique nature compared with other prions, and (3) functions related to meiotic drive and programmed cell death.
在丝状真菌中，营养细胞融合发生在个体内部和个体之间。来自两个个体的生长菌丝（吻合）的这些融合产生具有混合细胞质的双核细胞，称为异核体。异核体细胞的命运由名为（异核体）或（营养不亲和性）的特定基因座精细地进行遗传控制，作为自我/非自我识别系统的一部分。当两个个体的基因座不兼容时，产生的异核体细胞会经历程序性细胞死亡或显示出严重受损的真菌生长。在中，-是控制异核体不亲和性的至少九个等位基因之一，并且是改变的蛋白质构象[Het-s]朊病毒。本研究从以下几个方面描述了[Het-s]朊病毒：（1）基于早期遗传和生理学研究的历史发现，（2）与其他朊病毒相比基于其共同和独特性质构建的结构，以及（3）与减数分裂驱动和程序性细胞死亡相关的功能。
