Donayeva Ainur, Amanzholkyzy Ainur, Abdelazim Ibrahim A, Rakhyzhanova Saule, Mannapova Akzhunus, Abilov Talgar, Khamidullina Zaituna, Bimagambetova Karlygash, Gubasheva Gulnara, Kulzhanova Dinara, Turesheva Akbayan, Saparbayev Samat
Department of Normal Physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
Department of Obstetrics and Gynaecology, Faculty of Medicine Ain Shams University, Cairo, Egypt.
Prz Menopauzalny. 2024 Mar;23(1):1-5. doi: 10.5114/pm.2024.136327. Epub 2024 Mar 17.
To detect the relationship between 25-hydroxy vitamin D (25(OH)D) and adolescents' parathyroid hormone (PTH) and bone mineral density (BMD).
Two hundred adolescent girls were recruited for this cross-sectional comparative study. After detailed evaluation, a pelvic sonography was performed for the studied adolescents to rule out any pelvic pathology. Adolescents' blood samples were collected to measure the thyroid stimulating hormone, prolactin, glycosylated haemoglobin (HbA), PTH, and 25(OH)D. The studied adolescents' BMD and the T-score were evaluated at 2 anatomical sites. The studied adolescents were classified according to their serum 25(OH)D into 2 groups: a 25(OH)D-deficient group (study group; 25(OH)D < 20 ng/ml) and normal controls (25(OH)D > 30 ng/ml). Student's t-test was used for analysis of the studied adolescents' variables, and correlation analysis (Pearson`s correlation) was used to detect the relationship between 25(OH)D and adolescents' PTH and BMD.
The parathyroid hormone was statistically higher in the 25(OH)D-deficient group than in the normal controls (41.3 ±3.4 pg/ml vs. 21.1 ±2.8) ( = 0.02), and the BMD was statistically lower in the 25(OH)D-deficient group than in the normal controls (-1.25 ±0.5 vs. 0.3 ±0.4) ( = 0.01). The 25(OH)D had a significant negative correlation with the adolescents' PTH ( = -0.9175; p < 0.00001) and a significant positive correlation with the adolescents' BMD ( = 0.756; < 0.00001). The parathyroid hormone had a significant negative correlation with the adolescents' BMD ( = -0.7006; < 0.00001).
The parathyroid hormone in this study had significant negative correlations with both 25(OH)D and BMD. The 25(OH)D had a significant positive correlation with the studied adolescents' BMD.
检测25-羟维生素D（25(OH)D）与青少年甲状旁腺激素（PTH）及骨密度（BMD）之间的关系。
招募200名青春期女孩进行这项横断面比较研究。经过详细评估后，对研究对象进行盆腔超声检查以排除任何盆腔病变。采集青少年的血样以检测促甲状腺激素、催乳素、糖化血红蛋白（HbA）、PTH和25(OH)D。在2个解剖部位评估研究对象的骨密度和T值。根据血清25(OH)D将研究对象分为2组：25(OH)D缺乏组（研究组；25(OH)D<20 ng/ml）和正常对照组（25(OH)D>30 ng/ml）。采用学生t检验分析研究对象的变量，并采用相关性分析（Pearson相关性）检测25(OH)D与青少年PTH及骨密度之间的关系。
25(OH)D缺乏组的甲状旁腺激素在统计学上高于正常对照组（41.3±3.4 pg/ml对21.1±2.8）（P=0.02），且25(OH)D缺乏组的骨密度在统计学上低于正常对照组（-1.25±0.5对0.3±0.4）（P=0.01）。25(OH)D与青少年的PTH呈显著负相关（r=-0.9175；P<0.00001），与青少年的骨密度呈显著正相关（r=0.756；P<0.00001）。甲状旁腺激素与青少年的骨密度呈显著负相关（r=-0.7006；P<0.00001）。
本研究中甲状旁腺激素与25(OH)D和骨密度均呈显著负相关。25(OH)D与研究对象的骨密度呈显著正相关。
