Abdelazim Ibrahim A, Amer Osama O, Farghali Mohamed
Department of Obstetrics and Gynecology, Ain Shams University, Cairo, Egypt.
Department of Obstetrics and Gynecology, Ahmadi Hospital, Kuwait Oil Company, Ahmadi, Kuwait.
Prz Menopauzalny. 2020 Dec;19(4):179-183. doi: 10.5114/pm.2020.101948. Epub 2021 Jan 7.
Screening of polycystic ovary syndrome (PCOS) women for hypothyroidism and hyperprolactinemia was suggested, because the undiagnosed hypothyroidism and hyperprolactinemia can aggravate the PCOS symptoms.
To determine whether the insulin resistance (IR), hypothyroidism, and hyperprolactinemia are common endocrine disorders associated with the PCOS.
One hundred and twenty PCOS women were compared to 120 non-PCOS controls in this study. Participants' day 2-3 hormonal profile and insulin resistance (IR) using the fasting glucose and fasting insulin were evaluated. Collected data were analyzed to determine whether the IR, hypothyroidism, and hyperprolactinemia are common endocrine disorders associated with the PCOS.
TSH and prolactin were significantly high in PCOS women (6.4 ±4.2 and 934 ±102.3, respectively) than controls (3.5 ±3.3 and 445 ±77.5 mIU/ml, respectively) ( = 0.004 and 0.001, respectively). The PCOS women had significantly high relative risk of IR (RR 3.0 (95% CI: 1.9-4.7) < 0.0001), hypothyroidism (RR 3.4; 95% CI: 1.7-6.9) ( = 0.0005), and hyperprolactinaemia (RR 3.15; 95% CI: 1.8-5.6) ( = 0.0001) than controls. The PCOS women had higher odds of IR (OR 4.8; 95% CI: 2.6-8.8) ( < 0.0001), hypothyroidism (OR 4.29; 95% CI: 1.9-9.4) ( = 0.0003), and hyperprolactinaemia (OR 4.27; 95% CI: 2.1-8.5) ( < 0.0001) than controls.
TSH and prolactin were significantly high in studied PCOS women, and 47.5% of the studied PCOS women had IR. The PCOS women had significantly higher odds and relative risks of IR, hypothyroidism, and hyperprolactinemia than controls. IR, hypothyroidism, and hyperprolactinemia are common endocrine disorders associated with PCOS.
建议对多囊卵巢综合征（PCOS）女性进行甲状腺功能减退和高泌乳素血症筛查，因为未诊断出的甲状腺功能减退和高泌乳素血症会加重PCOS症状。
确定胰岛素抵抗（IR）、甲状腺功能减退和高泌乳素血症是否为与PCOS相关的常见内分泌疾病。
本研究将120例PCOS女性与120例非PCOS对照进行比较。评估参与者第2 - 3天的激素水平以及使用空腹血糖和空腹胰岛素评估胰岛素抵抗（IR）。对收集的数据进行分析，以确定IR、甲状腺功能减退和高泌乳素血症是否为与PCOS相关的常见内分泌疾病。
PCOS女性的促甲状腺激素（TSH）和泌乳素水平显著高于对照组（分别为6.4±4.2和934±102.3，而对照组分别为3.5±3.3和445±77.5 mIU/ml）（P值分别为0.004和0.001）。PCOS女性发生IR的相对风险显著较高（RR 3.0（95%CI：1.9 - 4.7），P<0.0001）、甲状腺功能减退（RR 3.4；95%CI：1.7 - 6.9）（P = 0.0005）以及高泌乳素血症（RR 3.15；95%CI：1.8 - 5.6）（P = 0.0001）。与对照组相比，PCOS女性发生IR的几率更高（OR 4.8；95%CI：2.6 - 8.8）（P<0.0001）、甲状腺功能减退（OR 4.29；95%CI：1.9 - 9.4）（P = 0.0003）以及高泌乳素血症（OR 4.27；95%CI：2.1 - 8.5）（P<0.0001）。
在研究的PCOS女性中，TSH和泌乳素水平显著升高，且47.5%的研究对象患有IR。与对照组相比，PCOS女性发生IR、甲状腺功能减退和高泌乳素血症的几率及相对风险显著更高。IR、甲状腺功能减退和高泌乳素血症是与PCOS相关的常见内分泌疾病。
