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源自真菌内生菌的代谢组学分析及其生物活性评估。

Metabolomic profiling of -derived fungal endophytes and evaluation of their biological activities.

作者信息

El Amir Dalia, Sayed Ahmed M, El-Hawary Seham S, Elsakhawy Omnia M, Attia Eman Zekry, Abdelmohsen Usama Ramadan, Mohammed Rabab

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University 62514 Beni-Suef Egypt

Department of Pharmacognosy, Collage of Pharmacy, Almaaqal University 61014 Basrah Iraq.

出版信息

RSC Adv. 2024 Apr 30;14(20):14296-14302. doi: 10.1039/d4ra00790e. eCollection 2024 Apr 25.

DOI:10.1039/d4ra00790e
PMID:38690109
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11059938/
Abstract

This study aimed to discover the potential of -derived fungal endophytes as a prospective source of bioactive metabolites. In the present study, three different strains of fungal endophyte were isolated from leaves L, roots T and stems St of to explore their biological and chemical diversity. These isolated fungi were exposed to different fermentation conditions by adding various chemical elicitors to their solid fermentation media. According to LC-HRESIMS-based metabolomics and multivariate analysis, each chemical treatment had a different effect on the chemical profiles of the fungi. Orthogonal Projections to Latent Structures Discriminant Analysis (OPLS-DA) proposed several compounds with anticancer action against MCF-7 (a human breast cancer cell line) and MDA-MB-231 (a human epithelial breast cancer cell line).

摘要

本研究旨在探索源自[植物名称]的真菌内生菌作为生物活性代谢物潜在来源的可能性。在本研究中，从[植物名称]的叶片L、根T和茎St中分离出三种不同的真菌内生菌菌株，以探究它们的生物学和化学多样性。通过向其固体发酵培养基中添加各种化学诱导剂，将这些分离出的真菌置于不同的发酵条件下。根据基于液相色谱-高分辨电喷雾电离质谱联用技术（LC-HRESIMS）的代谢组学和多变量分析，每种化学处理对真菌的化学图谱都有不同的影响。正交投影到潜在结构判别分析（OPLS-DA）提出了几种对MCF-7（一种人乳腺癌细胞系）和MDA-MB-231（一种人乳腺上皮癌细胞系）具有抗癌作用的化合物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3061/11059938/d9915c14df7f/d4ra00790e-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3061/11059938/dd280ba65358/d4ra00790e-f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3061/11059938/2ca9849d7e43/d4ra00790e-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3061/11059938/9571c6d1babe/d4ra00790e-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3061/11059938/95bb8ea8f1f2/d4ra00790e-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3061/11059938/d9915c14df7f/d4ra00790e-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3061/11059938/dd280ba65358/d4ra00790e-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3061/11059938/533d90884730/d4ra00790e-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3061/11059938/5a2d2f5b1a8f/d4ra00790e-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3061/11059938/d8d64c3a49fb/d4ra00790e-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3061/11059938/2ca9849d7e43/d4ra00790e-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3061/11059938/9571c6d1babe/d4ra00790e-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3061/11059938/95bb8ea8f1f2/d4ra00790e-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3061/11059938/d9915c14df7f/d4ra00790e-f8.jpg

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