一种通过点击反应固定染料的简单易行方法：无需活化炔烃和铜。
An easy and simple method for the immobilization of dyes through click reactions: activated alkyne, copper not needed.
作者信息
Sánchez-Bodón Julia, García-García Ane, Diaz-Galbarriatu Maria, Vilas-Vilela José Luis, Moreno-Benítez Isabel
机构信息
Grupo de Química Macromolecular (LABQUIMAC), Departamento de Química Física, Facultad de Ciencia y Tecnología, Universidad del País Vasco UPV/EHU 48940 Leioa Spain.
BCMaterials, Basque Center for Materials, Applications and Nanostructures UPV/EHU Science Park 48940 Leioa Spain.
出版信息
RSC Adv. 2024 Apr 30;14(20):14289-14295. doi: 10.1039/d4ra01776e. eCollection 2024 Apr 25.
The copper-free azide-alkyne click reaction has shown to be a successful alternative to immobilize covalently a fluorescente compound onto poly(-l-lactic) acid (PLLA) surfaces. Proceded by basic hydrolysis and amidation reaction, typical surface characterization techniques have validated each functionaliztion step and the success of the conjugation. This method offers a catalyst-free option for various surface conjugations, extremely demanded in biomedical and biosensory fields.
无铜叠氮化物-炔烃点击反应已被证明是一种将荧光化合物共价固定在聚（-l-乳酸）（PLLA）表面的成功替代方法。通过碱性水解和酰胺化反应进行，典型的表面表征技术已验证了每个功能化步骤以及共轭的成功。该方法为生物医学和生物传感领域极为需要的各种表面共轭提供了一种无催化剂的选择。
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