Škrlec Ivana, Kolomeichuk Sergey N
Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek 31000, Croatia.
Institute of Biology, Karelia Research Center of Russian Academy of Sciences, Petrozavodsk 185910, Russia.
World J Cardiol. 2024 Apr 26;16(4):181-185. doi: 10.4330/wjc.v16.i4.181.
Hypoxia-inducible factor 1 (HIF1) has a crucial function in the regulation of oxygen levels in mammalian cells, especially under hypoxic conditions. Its importance in cardiovascular diseases, particularly in cardiac ischemia, is because of its ability to alleviate cardiac dysfunction. The oxygen-responsive subunit, HIF1α, plays a crucial role in this process, as it has been shown to have cardioprotective effects in myocardial infarction through regulating the expression of genes affecting cellular survival, angiogenesis, and metabolism. Furthermore, expression induced reperfusion in the ischemic skeletal muscle, and hypoxic skin wounds in diabetic animal models showed reduced expression. Increased expression of has been shown to reduce apoptosis and oxidative stress in cardiomyocytes during acute myocardial infarction. Genetic variations in have also been found to correlate with altered responses to ischemic cardiovascular disease. In addition, a link has been established between the circadian rhythm and hypoxic molecular signaling pathways, with HIF1α functioning as an oxygen sensor and circadian genes such as period circadian regulator 2 responding to changes in light. This editorial analyzes the relationship between HIF1α and the circadian rhythm and highlights its significance in myocardial adaptation to hypoxia. Understanding the changes in molecular signaling pathways associated with diseases, specifically cardiovascular diseases, provides the opportunity for innovative therapeutic interventions, especially in low-oxygen environments such as myocardial infarction.
缺氧诱导因子1（HIF1）在调节哺乳动物细胞的氧水平方面具有关键作用，尤其是在缺氧条件下。它在心血管疾病，特别是心脏缺血中具有重要意义，这是因为它能够减轻心脏功能障碍。氧反应亚基HIF1α在这一过程中起着关键作用，因为它已被证明通过调节影响细胞存活、血管生成和代谢的基因表达，在心肌梗死中具有心脏保护作用。此外，在缺血骨骼肌中诱导再灌注时，以及在糖尿病动物模型的缺氧皮肤伤口中，其表达降低。在急性心肌梗死期间，其表达增加已被证明可减少心肌细胞的凋亡和氧化应激。还发现其基因变异与对缺血性心血管疾病的反应改变有关。此外，昼夜节律与缺氧分子信号通路之间已建立联系，HIF1α作为氧传感器发挥作用，而诸如周期昼夜调节因子2等昼夜节律基因则对光照变化作出反应。这篇社论分析了HIF1α与昼夜节律之间的关系，并强调了其在心肌适应缺氧中的重要性。了解与疾病，特别是心血管疾病相关的分子信号通路变化，为创新治疗干预提供了机会，尤其是在诸如心肌梗死等低氧环境中。
