Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Adv Protein Chem Struct Biol. 2023;137:225-267. doi: 10.1016/bs.apcsb.2023.02.004. Epub 2023 Feb 25.
Circadian rhythm regulates numerous physiological processes, and disruption of the circadian clock can lead to cardiovascular disease. Cardiovascular disease is the leading cause of morbidity and mortality worldwide. Small non-coding RNAs, microRNAs (miRNAs), are involved in regulating gene expression, both those important for the cardiovascular system and key circadian clock genes. Epigenetic mechanisms based on miRNAs are essential for fine-tuning circadian physiology. Indeed, some miRNAs depend on circadian periodicity, others are under the influence of light, and still others are under the influence of core clock genes. Dysregulation of miRNAs involved in circadian rhythm modulation has been associated with inflammatory conditions of the endothelium and atherosclerosis, which can lead to coronary heart disease and myocardial infarction. Epigenetic processes are reversible through their association with environmental factors, enabling innovative preventive and therapeutic strategies for cardiovascular disease. Here, is a review of recent findings on how miRNAs modulate circadian rhythm desynchronization in cardiovascular disease. In the era of personalized medicine, the possibility of treatment with miRNA antagomirs should be time-dependent to correspond to chronotherapy and achieve the most significant efficacy.
昼夜节律调节着许多生理过程，而昼夜节律的破坏会导致心血管疾病。心血管疾病是全球发病率和死亡率的主要原因。小的非编码 RNA，即 microRNAs（miRNAs），参与调节基因表达，包括对心血管系统重要的基因和关键的昼夜节律钟基因。基于 miRNAs 的表观遗传机制对于精细调节昼夜生理学至关重要。事实上，一些 miRNAs 依赖于昼夜节律的周期性，另一些则受光的影响，还有一些则受核心时钟基因的影响。参与昼夜节律调节的 miRNAs 的失调与内皮细胞和动脉粥样硬化的炎症状态有关，这可能导致冠心病和心肌梗死。通过与环境因素的关联，表观遗传过程是可逆的，从而为心血管疾病提供了创新的预防和治疗策略。本文综述了最近关于 miRNAs 如何调节心血管疾病中昼夜节律失调的发现。在个性化医疗时代，miRNA 拮抗剂的治疗可能性应该是时间依赖性的，以对应于时间治疗，并实现最大的疗效。
