Gupta Sonia, Alruwaili Khalid Hussain A, Escobedo Rosa Llisel Ocampo, Pangarkar Manasi, Chawla Jatinder Pal Singh, Sunitha S, Qureshi Kinza, Yadav Achla Bharti
Department of Oral Pathology and Microbiology and Forensic Odontology, Rayat and Bahra Dental College and Hospital, Kharar, Mohali, Punjab, India.
Dental Intern, College of Dentistry, Jouf University, Sakaka, Kingdom of Saudi Arabia.
Natl J Maxillofac Surg. 2024 Jan-Apr;15(1):3-17. doi: 10.4103/njms.njms_79_23. Epub 2024 Mar 19.
Distant metastasis to salivary glands is a very rare event. Renal cell carcinoma (RCC) has been known for its high propensity of metastasis to unusual locations and salivary glands are one among those sites. Approximately 0.1% of all salivary gland metastatic neoplasms originate from renal malignancies Literature has reported several studies analysing the metastatic tumors to the oral region. However, very little research work has been published to date to analyse solely the RCC metastasizing to the salivary glands. Thus, this review was conducted to examine the published cases of RCC metastasizing to salivary glands in the literature to date and to learn about their characteristics. An electronic search of the published literature was performed without publication year limitation in PubMed/ Medline, Scopus, Google Scholar, Web of Science, Science Direct, Embase, and Research Gate databases, using mesh keywords like ('Renal cancer', OR 'Renal carcinoma' OR 'Renal cell cancer' OR 'Renal cell carcinoma'), AND ('Metastasis' OR 'Metastases'), And ('Salivary glands' OR 'Parotid gland' OR 'Submandibular gland' OR 'Sublingual gland'). We also searched all related journals manually. The reference list of all articles was also checked. Our research revealed a total of 83 relevant papers (1965-2022) with 100 patients. Parotid was the most predominant gland affected. 8% of patients died with a mean survival time of 1.3 yr. From this research, it can be concluded that RCC metastasizing to salivary glands is a rare occurrence. Careful evaluation of these cases is needed in order to raise awareness of these lesions and gain a better understanding of their characteristics for clinical as well as global implications.
唾液腺远处转移是一种非常罕见的情况。肾细胞癌（RCC）以其易于转移至不寻常部位而闻名，唾液腺就是其中之一。所有唾液腺转移性肿瘤中约0.1%起源于肾脏恶性肿瘤。文献报道了多项分析口腔区域转移性肿瘤的研究。然而，迄今为止，仅有极少的研究专门分析了转移至唾液腺的肾细胞癌。因此，本综述旨在研究迄今为止文献中已发表的肾细胞癌转移至唾液腺的病例，并了解其特征。在PubMed/Medline、Scopus、谷歌学术、科学网、Science Direct、Embase和Research Gate数据库中，使用“肾癌”、“肾细胞癌”、“转移”、“唾液腺”等主题词，对已发表文献进行了不限出版年份的电子检索。我们还手动检索了所有相关期刊，并检查了所有文章的参考文献列表。我们的研究共发现83篇相关论文（1965 - 2022年），涉及100例患者。腮腺是最常受累的腺体。8%的患者死亡，平均生存时间为1.3年。从这项研究可以得出结论，肾细胞癌转移至唾液腺是一种罕见情况。需要对这些病例进行仔细评估，以提高对这些病变的认识，并更好地了解其特征，从而对临床和全球范围产生影响。
