Diagnostic Center for Oral Diseases, School of Dentistry, Universidade Federal de Pelotas, Pelotas, Brazil.
Department of Oral Diagnosis, Piracicaba Dental School, Universidade de Campinas, Piracicaba, Brazil.
Oral Dis. 2022 Jan;28(1):23-32. doi: 10.1111/odi.13611. Epub 2020 Sep 9.
The purpose of this systematic review was to incorporate the information published on metastatic lesions in the in the oral and maxillofacial region into a comprehensive analysis of their demographic, clinical, and imaginological features and survival rate.
An electronic search was undertaken in the subsequent databases: PubMed, Web of Science, Scopus, EMBASE, and LILACS. All papers included were case reports or case series. Absolute and relative frequencies were obtained by descriptive analysis. Overall survival was defined by the Kaplan-Meier method.
This systematic review identified 217 studies from 33 countries, comprising 348 cases. Male individuals were more affected (n = 199/57.68%) in the 5th to 7th decades of life. The most usual primary site was the lung in men (n = 49/14.08%) and the breast in women (n = 40/11.49%). Jawbones were affected in 183 cases (53.19%), with the posterior mandible (n = 96/66.66%) representing the preferred site. In soft tissues, the gingiva (n = 80/23.25%) was more affected. Clinical presentation was a nodular mass with or without ulceration (n = 280/85.89%). Imaginological examinations revealed radiolucent/hypodense lesions (n = 115/59.28%). The mean survival time was eight months.
Despite the rare occurrence of metastatic lesions in the oral and maxillofacial region, the current systematic review offers substantial data that could assist clinicians and surgeons.
本系统评价的目的是将发表的关于口腔颌面部转移瘤的信息纳入对其人口统计学、临床和影像学特征以及生存率的综合分析。
在随后的数据库中进行了电子检索：PubMed、Web of Science、Scopus、EMBASE 和 LILACS。所有纳入的论文均为病例报告或病例系列。通过描述性分析获得绝对和相对频率。总体生存率定义为 Kaplan-Meier 法。
本系统评价从 33 个国家确定了 217 项研究，共 348 例。男性（n=199/57.68%）在 50 至 70 岁的年龄段受影响更大。最常见的原发部位是男性的肺部（n=49/14.08%）和女性的乳房（n=40/11.49%）。183 例（53.19%）颌骨受累，后下颌骨（n=96/66.66%）为首选部位。在软组织中，牙龈（n=80/23.25%）受影响更大。临床表现为有或无溃疡的结节性肿块（n=280/85.89%）。影像学检查显示透亮/低密病变（n=115/59.28%）。平均生存时间为 8 个月。
尽管口腔颌面部转移瘤的发生率较低，但本系统评价提供了大量数据，可为临床医生和外科医生提供帮助。
