Medicine II, Nursing/Palliative Care, University of Medicine and Pharmacy, Grigore T. Popa, Iasi, Romania.
Expert Rev Respir Med. 2024 Mar-Apr;18(3-4):99-110. doi: 10.1080/17476348.2024.2349579. Epub 2024 May 7.
Non-small cell lung cancer (NSCLC) is a disease commonly diagnosed in the elderly, often in advanced stages. However, elderly patients with lung cancer can benefit from surgery, provided that postoperative risks are assessed appropriately before surgery. Frailty is a measure of age-related impaired functional status and a predictor of mortality and morbidity. However, its importance as a preoperative marker is not well defined.
This systematic review discusses the importance of preoperative frailty screening in elderly patients with NSCLC. A literature search was performed on the MEDLINE database in June 2023, and relevant studies on frailty or preoperative assessment of NSCLC which were published between 2000 and 2023 were retained and discussed in this review.
Among the types of existing methods used to assess frailty those on the geriatric assessment seem to be the most appropriate; however, they are unable to fully capture the 'surgical' frailty; thus, other instruments should be developed and validated in NSCLC.
非小细胞肺癌（NSCLC）是一种常见于老年人的疾病，通常处于晚期。然而，只要在手术前适当地评估术后风险，老年肺癌患者仍可从手术中获益。虚弱是衡量与年龄相关的功能状态受损的一种方法，也是死亡率和发病率的预测指标。然而，其作为术前标志物的重要性尚未得到明确界定。
本系统评价讨论了术前虚弱筛查在老年 NSCLC 患者中的重要性。2023 年 6 月在 MEDLINE 数据库中进行了文献检索，保留了 2000 年至 2023 年期间发表的关于虚弱或 NSCLC 术前评估的相关研究，并在本综述中进行了讨论。
在现有的评估虚弱类型的方法中，老年综合评估似乎是最合适的；然而，它们无法完全捕捉到“手术”相关的虚弱；因此，应该开发和验证其他适用于 NSCLC 的工具。
