微小 RNA-181 在心血管疾病中的作用：新兴的生物标志物和治疗靶点。
MicroRNA-181 in cardiovascular disease: Emerging biomarkers and therapeutic targets.
机构信息
Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
出版信息
FASEB J. 2024 May 15;38(9):e23635. doi: 10.1096/fj.202400306R.
Abstract
Cardiovascular disease (CVD) is the leading cause of death worldwide. MicroRNAs (MiRNAs) have attracted considerable attention for their roles in several cardiovascular disease states, including both the physiological and pathological processes. In this review, we will briefly describe microRNA-181 (miR-181) transcription and regulation and summarize recent findings on the roles of miR-181 family members as biomarkers or therapeutic targets in different cardiovascular-related conditions, including atherosclerosis, myocardial infarction, hypertension, and heart failure. Lessons learned from these studies may provide new theoretical foundations for CVD.
摘要
心血管疾病（CVD）是全球范围内的主要死亡原因。MicroRNAs（miRNAs）在几种心血管疾病状态中的作用引起了相当大的关注，包括生理和病理过程。在这篇综述中，我们将简要描述 microRNA-181（miR-181）的转录和调节，并总结最近关于 miR-181 家族成员作为生物标志物或治疗靶点在不同心血管相关疾病中的作用的研究发现，包括动脉粥样硬化、心肌梗死、高血压和心力衰竭。从这些研究中获得的经验教训可能为 CVD 提供新的理论基础。
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