微小 RNA 介导运动对心脏的有益作用。
MicroRNAs Mediate Beneficial Effects of Exercise in Heart.
机构信息
Cardiac Regeneration and Ageing Lab, School of Life Science, Shanghai University, Shanghai, 200444, China.
Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
出版信息
Adv Exp Med Biol. 2017;1000:261-280. doi: 10.1007/978-981-10-4304-8_15.
MicroRNAs (miRNAs, miRs), a group of small non-coding RNAs, repress gene expressions at posttranscriptional level in most cases and are involved in cardiovascular physiology and disease pathogenesis. Increasing evidence has proved that miRNAs are potential regulators of exercise induced cardiac growth and mediate the benefits of exercise in a variety of cardiovascular diseases. In this chapter, we will review the regulatory effects of miRNAs in cardiac adaptations to exercise, and summarize their cardioprotective effects against myocardial infarction, ischemia/reperfusion injury, heart failure, diabetic cardiomyopathy, atherosclerosis, hypertension, and pulmonary hypertension. Also, we will introduce circulating miRNAs in response to acute and chronic exercise. Therefore, miRNAs may serve as novel therapeutic targets and potential biomarkers for cardiovascular diseases.
微小 RNA（miRNAs，miRs）是一组小型非编码 RNA，在大多数情况下在转录后水平抑制基因表达，参与心血管生理学和疾病发病机制。越来越多的证据证明，miRNAs 是运动诱导的心脏生长的潜在调节因子，并在多种心血管疾病中介导运动的益处。在本章中，我们将回顾 miRNAs 在心脏适应运动中的调节作用，并总结它们在心肌梗死、缺血/再灌注损伤、心力衰竭、糖尿病心肌病、动脉粥样硬化、高血压和肺动脉高压中的心脏保护作用。此外，我们将介绍对急性和慢性运动的反应的循环 miRNAs。因此，miRNAs 可能成为心血管疾病的新型治疗靶点和潜在生物标志物。
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