Department of Plastic & Reconstructive Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Department of Plastic & Reconstructive Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Oral Oncol. 2024 Jun;153:106813. doi: 10.1016/j.oraloncology.2024.106813. Epub 2024 Apr 30.
Long-term health-related quality of life (HRQOL) is frequently affected in head and neck cancer (HNC) survivors. Due to the shortage of studies investigating long-term patient-reported outcomes, we investigated long-term HRQOL using the novel FACE-Q HNC Module.
A retrospective cross-sectional single-center study was performed, including all patients who underwent curative treatment for HNC between 2006 and 2013. All eligible patients (n = 863) were invited to participate of whom 540 completed the questionnaires. Additionally, a prospective longitudinal cohort of 43 HNC patients treated between 2020 and 2022 was included who preoperatively filled in the FACE-Q, and at three, six, and 12 months postoperatively. HRQOL domain scores were analyzed to visualize group characteristics by tumor site and type of surgical resection.
Both surgical and non-surgical HNC treatments predominantly affected long-term functional HRQOL domains (eating, salivation, speech, and swallowing), eating distress, and speaking distress, with distinct profiles depending on tumor site and type of treatment. In contrast, few long-term intergroup differences between HNC patients were observed for appearance, smiling, drooling distress, and smiling distress. Longitudinal data showed significant deterioration across all functional HRQOL domains in the short-term following treatment. Patients predominantly reported long-lasting negative treatment effects at 12 months follow-up for functional domains, whereas psychological domains showed near-complete recovery at group level.
At long-term, various function-related and psychosocial HRQOL domains still are affected in head and neck cancer survivors. The results may serve to better inform patients with regard to specific treatments and highlight HRQOL domains which may potentially be optimized.
头颈部癌症（HNC）幸存者的长期健康相关生活质量（HRQOL）经常受到影响。由于缺乏研究调查长期患者报告的结果，我们使用新的 FACE-Q HNC 模块调查了长期 HRQOL。
进行了一项回顾性横断面单中心研究，包括 2006 年至 2013 年间接受根治性治疗的所有 HNC 患者。邀请所有符合条件的患者（n=863）参加，其中 540 人完成了问卷。此外，还纳入了 2020 年至 2022 年期间接受治疗的 43 名 HNC 患者的前瞻性纵向队列，这些患者在术前填写了 FACE-Q，并在术后 3、6 和 12 个月进行了评估。分析 HRQOL 域评分，以通过肿瘤部位和手术切除类型可视化组特征。
手术和非手术 HNC 治疗主要影响长期功能 HRQOL 域（进食、唾液、言语和吞咽）、进食困扰和言语困扰，其特征取决于肿瘤部位和治疗类型。相比之下，HNC 患者之间很少观察到长期的外观、微笑、流涎困扰和微笑困扰的组间差异。纵向数据显示，治疗后短期所有功能 HRQOL 域均显著恶化。患者主要报告在 12 个月随访时，功能域存在持久的负面治疗效果，而心理域在组水平上几乎完全恢复。
在长期，头颈部癌症幸存者的各种与功能相关和心理社会 HRQOL 域仍受到影响。结果可用于更好地告知患者特定的治疗方法，并突出可能需要优化的 HRQOL 域。
