Department of Pathology, Pathology and Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Department of Pathology, Hospital Universitari Vall d'Hebron, Passeig de la Vall d'Hebron 119-129, 08035 Barcelona, Catalunya, Spain.
Surg Pathol Clin. 2024 Jun;17(2):159-171. doi: 10.1016/j.path.2023.11.003. Epub 2023 Dec 7.
In the twenty- first century, there is widespread agreement that in addition to lung cancer, emphysema, and chronic bronchitis, cigarette smoking causes accumulation of pigmented macrophages, interstitial fibrosis, and Langerhans cell proliferation in various permutations. These histologic changes remain subclinical in some patients and produce clinical manifestations and imaging abnormalities in others. Debate surrounds terminology of these lesions, which are often grouped together under the umbrella of "smoking-related interstitial lung disease." This review summarizes modern concepts in our understanding of these abnormalities and explains how the recognition of smoking-related interstitial fibrosis has advanced the field.
在 21 世纪，人们普遍认为，除了肺癌、肺气肿和慢性支气管炎之外，吸烟还会导致各种组合形式的色素巨噬细胞、间质纤维化和朗格汉斯细胞增殖。在一些患者中，这些组织学变化仍然处于亚临床状态，而在另一些患者中则会出现临床表现和影像学异常。围绕这些病变的术语存在争议，这些病变通常被归为“与吸烟相关的间质性肺疾病”的范畴。这篇综述总结了我们对这些异常的现代理解概念，并解释了如何识别与吸烟相关的间质性纤维化推动了这一领域的发展。
