吸入镁与吸入沙丁胺醇治疗儿童中重度哮喘急性发作的疗效比较。
Inhaled magnesium versus inhaled salbutamol in rescue treatment for moderate and severe asthma exacerbations in pediatric patients.
机构信息
Faculdade de Medicina de Botucatu, Departamento de Pediatria, Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP), Botucatu, SP, Brazil.
Faculdade de Medicina de Botucatu, Departamento de Pediatria, Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP), Botucatu, SP, Brazil.
出版信息
J Pediatr (Rio J). 2024 Sep-Oct;100(5):539-543. doi: 10.1016/j.jped.2024.03.012. Epub 2024 Apr 30.
OBJECTIVE
To compare the effectiveness of inhaled Magnesium Sulfate associated with Salbutamol versus Inhaled Salbutamol alone in patients with moderate and severe asthma exacerbations.
METHOD
Clinical, prospective and randomized study with patients between 3 and 14 years of age divided into two groups: one to receive inhaled salbutamol associated with magnesium sulfate (GSM), the other to receive inhaled salbutamol alone (GS). The sample consisted of 40 patients, 20 patients in each group. Severity was classified using the modified Wood-Downes score, with values between 4 and 7 classified as moderate and 8 or more classified as severe.
RESULTS
Post-inhalation scores decreased both in patients who received salbutamol and magnesium and in those who received salbutamol alone, with no statistically significant difference between the groups.
CONCLUSIONS
Despite the benefits when administered intravenously, inhalation of the drug alone or in combination did not reduce the severity of the exacerbation.
目的
比较吸入硫酸镁联合沙丁胺醇与单独吸入沙丁胺醇治疗中重度哮喘急性发作的疗效。
方法
这是一项临床、前瞻性、随机研究，纳入年龄在 3 至 14 岁之间的患者，分为两组：一组接受吸入硫酸沙丁胺醇联合硫酸镁（GSM）治疗，另一组接受单独吸入沙丁胺醇（GS）治疗。该研究共纳入 40 例患者，每组 20 例。采用改良 Wood-Downes 评分对病情严重程度进行分类，评分在 4 至 7 分之间为中度，8 分及以上为重度。
结果
吸入沙丁胺醇和硫酸镁的患者以及单独吸入沙丁胺醇的患者，在吸入后评分均降低，两组间无统计学差异。
结论
尽管静脉内给药有一定益处，但单独或联合吸入该药物并不能降低病情加重的严重程度。
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