Department of Anthropology, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland.
Department of Mechanics, Materials and Biomedical Engineering, Faculty of Mechanical Engineering, Wroclaw University of Science and Technology, Wrocław, Poland.
Sci Rep. 2024 May 1;14(1):9977. doi: 10.1038/s41598-024-59946-z.
This paper investigates trabecular bone ontogenetic changes in two different Polish populations, one prehistoric and the other historical. The studied populations are from the Brześć Kujawski region in Kujawy (north-central Poland), one from the Neolithic Period (4500-4000 BC) and one from the Middle Ages (twelfth-sixteenth centuries AD), in total 62 vertebral specimens (32 males, 30 females). Eight morphometric parameters acquired from microCT scan images were analysed. Two-way ANOVA after Box-Cox transformation and multifactorial regression model were calculated. A significant decrease in percentage bone volume fraction (BV/TV; [%]) with age at death was observed in the studied sample; Tb.N (trabecular number) was also significantly decreased with age; trabecular separation (Tb.Sp) increased with advancing age; connectivity density (Conn.D) was negatively correlated with biological age and higher in the Neolithic population. These data are found to be compatible with data from the current biomedical literature, while no loss of horizontal trabeculae was recorded as would be expected based on modern osteoporosis.
本文研究了两个不同波兰人群的小梁骨发育变化，一个是史前人群，另一个是历史人群。研究人群来自波兰库亚维的布热斯瓦夫库亚维地区，一个来自新石器时代（公元前 4500-4000 年），另一个来自中世纪（公元 12-16 世纪），共有 62 个椎体标本（32 名男性，30 名女性）。对微 CT 扫描图像获得的 8 个形态计量参数进行了分析。经过 Box-Cox 变换的双因素方差分析和多因素回归模型计算。在研究样本中，观察到骨体积分数（BV/TV；[%]）随死亡年龄的显著下降；Tb.N（骨小梁数量）也随年龄的增加而显著减少；骨小梁间隔（Tb.Sp）随年龄的增加而增加；连接密度（Conn.D）与生物年龄呈负相关，在新石器时代人群中更高。这些数据与当前生物医学文献中的数据是一致的，而没有记录到现代骨质疏松症所预期的水平骨小梁丢失。
