2023 年亮点：嵌合抗原受体 T 细胞推动自身免疫性疾病的精准治疗。
Highlight of 2023: CAR T cells driving precision therapy for autoimmune disease.
机构信息
Centre for Immunology and Allergy Research, Westmead Institute for Medical Research and Faculty of Medicine and Health, University of Sydney, Westmead, NSW, Australia.
Department of Immunology, Westmead Hospital and Institute of Clinical Pathology and Medical Research, NSW Health Pathology, Westmead, NSW, Australia.
出版信息
Immunol Cell Biol. 2024 Jul;102(6):437-440. doi: 10.1111/imcb.12766. Epub 2024 May 1.
CAR T cell therapy is showing remarkable results in autoimmune disease with treatment-refractory patients showing durable drug-free remission. Here, we highlight five key papers from 2023 that are driving the development of CAR T cells to improve precision, safety, efficacy and accessibility for the treatment of autoantibody-associated autoimmune diseases.
嵌合抗原受体 T 细胞疗法在治疗难治性自身免疫疾病患者方面显示出显著的效果，这些患者在无需药物治疗的情况下实现了持久缓解。在此，我们重点介绍 2023 年的五篇关键论文，这些论文推动了嵌合抗原受体 T 细胞的发展，以提高治疗自身抗体相关自身免疫疾病的精准性、安全性、疗效和可及性。
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