Neurosurgery Unit, Department of Neuroscience "Rita Levi Montalcini", "Città della Salute e della Scienza" University Hospital, University of Turin, Turin, Italy.
Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Technol Cancer Res Treat. 2024 Jan-Dec;23:15330338241249026. doi: 10.1177/15330338241249026.
Laser Interstitial Thermotherapy is a minimally invasive treatment option in neurosurgery for intracranial tumors, including recurrent gliomas. The technique employs the thermal ablation of target tissue to achieve tumor control with real-time monitoring of the extent by magnetic resonance thermometry, allowing targeted thermal injury to the lesion. Laser Interstitial Thermotherapy has gained interest as a treatment option for recurrent gliomas due to its minimally invasive nature, shorter recovery times, ability to be used even in patients with numerous comorbidities, and potential to provide local tumor control. It can be used as a standalone treatment or combined with other therapies, such as chemotherapy or radiation therapy. We describe the most recent updates regarding several studies and case reports that have evaluated the efficacy and safety of Laser Interstitial Thermotherapy for recurrent gliomas. These studies have reported different outcomes, with some demonstrating promising results in terms of tumor control and patient survival, while others have shown mixed outcomes. The success of Laser Interstitial Thermotherapy depends on various factors, including tumor characteristics, patient selection, and the experience of the surgical team, but the future direction of treatment of recurrent gliomas will include a combined approach, comprising Laser Interstitial Thermotherapy, particularly in deep-seated brain regions. Well-designed prospective studies will be needed to establish with certainty the role of Laser Interstitial Thermotherapy in the treatment of recurrent glioma.
激光间质热疗是一种用于颅内肿瘤（包括复发性脑胶质瘤）的神经外科微创手术选择。该技术通过磁共振测温实时监测靶组织的热消融程度，实现肿瘤控制，从而对病变进行靶向热损伤。由于其微创性、较短的恢复时间、即使在合并多种疾病的患者中也能使用的能力以及提供局部肿瘤控制的潜力，激光间质热疗作为复发性脑胶质瘤的治疗选择已引起关注。它可以单独使用，也可以与化疗或放疗等其他疗法联合使用。我们描述了最近关于几项研究和病例报告的更新，这些研究评估了激光间质热疗治疗复发性脑胶质瘤的疗效和安全性。这些研究报告了不同的结果，一些研究在肿瘤控制和患者生存方面显示出有希望的结果，而另一些研究则显示出混合结果。激光间质热疗的成功取决于多种因素，包括肿瘤特征、患者选择和手术团队的经验，但复发性脑胶质瘤的未来治疗方向将包括联合治疗，特别是在深部脑区，将包括激光间质热疗。需要进行精心设计的前瞻性研究，以确定激光间质热疗在复发性脑胶质瘤治疗中的作用。
