Bradley Danielle, Sarpaki Sophia, Mirabello Vincenzo, Giuffrida Simone Giuseppe, Kociok-Köhn Gabriele I, Calatayud David G, Pascu Sofia I
Department of Chemistry, University of Bath Claverton Down Rd. BA2 7AY Bath UK
Department of Inorganic Chemistry, Faculty of Sciences, Universidad Autónoma de Madrid Campus de Cantoblanco, Francisco Tomas y Valiente 7, Madrid 28049 Spain
Nanoscale Adv. 2024 Jan 10;6(9):2287-2305. doi: 10.1039/d3na01042b. eCollection 2024 Apr 30.
Coumarins, methylene blue derivatives, as well as related functional organic dyes have become prevalent tools in life sciences and biomedicine. Their intense blue fluorescence emission makes them ideal agents for a range of applications, yet an unwanted facet of the interesting biological properties of such probes presents a simultaneous environmental threat due to inherent toxicity and persistence in aqueous media. As such, significant research efforts now ought to focus on their removal from the environment, and the sustainable trapping onto widely available, water dispersible and processable adsorbent structures such as graphene oxides could be advantageous. Additionally, flat and aromatic bis(thiosemicarbazones) (BTSCs) have shown biocompatibility and chemotherapeutic potential, as well as intrinsic fluorescence, hence traceability in the environment and in living systems. A new palette of graphene oxide-based hierarchical supramolecular materials incorporating BTSCs were prepared, characterised, and reported hereby. We report on the supramolecular entrapping of several flat, aromatic fluorogenic molecules onto graphene oxide on basis of non-covalent interactions, by virtue of their structural features with potential to form aromatic stacks and H-bonds. The evaluations of the binding interactions in solution by between organic dyes (methylene blue and functional coumarins) and new graphene oxide-anchored Zn(ii) derivatised bis(thiosemicarbazones) nanohybrids were carried out by UV-Vis and fluorescence spectroscopies.
香豆素、亚甲蓝衍生物以及相关的功能性有机染料已成为生命科学和生物医学中普遍使用的工具。它们强烈的蓝色荧光发射使其成为一系列应用的理想试剂，然而，由于此类探针具有有趣的生物学特性，但其固有的毒性和在水性介质中的持久性同时对环境构成威胁。因此，目前大量的研究工作应集中在将它们从环境中去除，而将其可持续捕获到广泛可用、水分散且可加工的吸附剂结构（如氧化石墨烯）上可能具有优势。此外，平面芳香族双（硫代半卡巴腙）（BTSCs）已显示出生物相容性和化疗潜力，以及固有荧光，因此在环境和生物系统中具有可追溯性。本文制备、表征并报道了一种基于氧化石墨烯并结合BTSCs 的新型分级超分子材料系列。我们基于非共价相互作用，凭借其具有形成芳香堆叠和氢键潜力的结构特征，报道了几种平面芳香族荧光分子在氧化石墨烯上的超分子捕获。通过紫外可见光谱和荧光光谱对有机染料（亚甲蓝和功能性香豆素）与新型氧化石墨烯锚定锌（II）衍生双（硫代半卡巴腙）纳米杂化物之间在溶液中的结合相互作用进行了评估。
