可见光诱导的苯胺与4-羟基丁-2-酮的烷基化反应

Jiang Liya, Ni Ling, Tang Xinyue, Baell Jonathan B, Huang Fei, Ren Lanhui

School of Pharmaceutical Sciences, Nanjing Tech University Nanjing 211816 China

Institute of Zhejiang University-Quzhou 99 Zheda Road Quzhou Zhejiang Province 324000 China

RSC Adv. 2024 May 1;14(20):14452-14455. doi: 10.1039/d4ra01339e. eCollection 2024 Apr 25.

The synthesis of amines through -alkylation is particularly attractive. Herein, a strategy for visible-light-induced -alkylation of anilines with 4-hydroxybutan-2-one was developed in the presence of NHBr, which avoid the use of metals, bases and ligands. In addition, gram-scale experiments proved that the system has the potential to be scaled.

通过β-烷基化合成胺类化合物特别具有吸引力。在此，开发了一种在NHBr存在下，以4-羟基丁-2-酮对苯胺进行可见光诱导β-烷基化的策略，该策略避免了使用金属、碱和配体。此外，克级实验证明该体系具有扩大规模的潜力。