Li Xiao-Lan, Li Min, Wang Ling-Zhi, Tian Juan, Shi Zi-Wei, Song Kui
Department of Hematology, The First Affiliated Hospital of Jishou University, Jishou, Hunan 416000, P.R. China.
Department of Pharmacy, The First Affiliated Hospital of Jishou University, Jishou, Hunan 416000, P.R. China.
Oncol Lett. 2024 Apr 19;27(6):274. doi: 10.3892/ol.2024.14407. eCollection 2024 Jun.
Acute promyelocytic leukemia (APL), especially cases of high-risk with complex chromosomes (CK), is rare in individuals infected with human immunodeficiency virus (HIV), making the establishment of therapeutic approaches challenging; often the treatment is individualized. This report describes a 49-year-old female patient with HIV who was diagnosed with high-risk APL with a new CK translocation and presents a literature review. At diagnosis, the patient presented with typical t(15;17)(q24;q21) with additional abnormalities, including add(5)(q15), add(5)(q31), add(7)(q11.2) and add(12) (p13). The results of acute myeloid leukemia mutation analysis suggested positivity for calreticulin and lysine methyltransferase 2C genes. The patient received all-trans retinoic acid combined with arsenic trioxide and chemotherapy, with morphologically complete remission after the first cycle of chemotherapy. The present report provided preliminary data for future clinical research.
急性早幼粒细胞白血病（APL），尤其是伴有复杂染色体（CK）的高危病例，在感染人类免疫缺陷病毒（HIV）的个体中较为罕见，这使得治疗方法的确定具有挑战性；治疗通常需要个体化。本报告描述了一名49岁的HIV感染女性患者，她被诊断为伴有新的CK易位的高危APL，并进行了文献综述。诊断时，患者表现为典型的t(15;17)(q24;q21)以及其他异常，包括add(5)(q15)、add(5)(q31)、add(7)(q11.2)和add(12)(p13)。急性髓系白血病突变分析结果显示钙网蛋白和赖氨酸甲基转移酶2C基因呈阳性。该患者接受了全反式维甲酸联合三氧化二砷及化疗，化疗第一个周期后达到形态学完全缓解。本报告为未来的临床研究提供了初步数据。
